Hepatitis B virus (HBV) infection is a dynamic process which involves several variable biochemical, virological and histological profiles at different stages of the infection. This depends on host and viral factors. Furthermore, this profile may change at a variable pace over time. The correlation between detection of T-cell response and HBV load in chronic HBV infection remains unknown.
In each of the clinical stages of chronic HBV infection, whether the composition of T-cell subpopulations is different and relates to viral load. Thus characterization of T-cell profile is relevant to improved understanding of chronic HBV infection and the design of antiviral therapy.
A research article to be published on July 21, 2009 in the World Journal of Gastroenterology addresses this question. The research team, led by Professor Jing You from the Department of Infectious Diseases of the First Affiliated Hospital of Kunming Medical University of China and the Epidemiology Unit of the Faculty of Medicine of Prince of Songkla University of Thailand, investigated the peripheral T-cell subpopulation profiles and their correlation with viral replication in different clinical stages of chronic HBV infection. The article further indicated that the clinical stages of chronic HBV infection, separated on virological and biochemical parameters, have characteristic peripheral T-cell subpopulation profiles. HBV load, in patients at immune-tolerant and -active stages, contributes to the variations of peripheral T cell subpopulation profiles.