Results from the COMMANDER Heart Failure trial were published in JAMA Cardiology.
Heart failure, sometimes known as congestive heart failure, occurs when your heart muscle doesn't effectively pump blood. Certain conditions that narrow arteries, such as coronary artery disease or high blood pressure, gradually weaken or stiffen the heart, reducing its ability to fill and pump efficiently. Researchers say these conditions elevate patients' risk for subsequent issues.
"We initially wanted to know if we could improve outcomes in patients after an episode of worsening heart failure using a low dose of blood thinner. What we found was that, while this strategy didn't accomplish that goal, it was associated with a significant reduction in the risk of clinically important events that are caused by thrombosis -- stroke, heart attack and sudden cardiac death."
According to the Centers for Disease Control and Prevention, approximately 610,000 people die of heart disease in the United States annually -- that's one in every four deaths nationwide. Heart disease is the leading cause of death for both men and women.
The international, randomized COMMANDER HF study included 5,022 patients after discharge from a hospital or in treatment in an outpatient clinic for worsening heart failure. Patients were given 2.5 milligrams of rivaroxaban (a blood thinner marketed as Xarelto) orally twice daily or a placebo in addition to their standard therapy.
"Although there was some increase in bleeding risk with low-dose rivaroxaban, major bleeding, which was the primary safety endpoint of the study, was not significantly increased," said Greenberg. "This is an important observation because currently there is no mandate in place for physicians to prescribe blood thinners to this patient population."
Researchers say future steps include confirmation of findings in prospective, large clinical trials.
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