The deadly bat-borne lyssavirus gets its first victim, a horse.
Biosecurity Queensland said the horse was euthanised last week after falling ill with what was initially suspected to be infection with another deadly virus, Hendra, which has killed four Australians since its discovery in 1994.
Tests were negative for Hendra but came back positive for Australian bat lyssavirus (ABLV) -- the first time a horse has been known to contract the disease, similar to rabies, which is even more fatal to humans than Hendra.
"There is a theoretical possibility that transmission to humans could occur."
Lyssavirus in humans causes paralysis, delirium, convulsions, and ultimately death, usually due to respiratory paralysis.
All three Australians infected with lyssavirus since its discovery in 1996 have died. Until now all human cases have been via direct contact with an infected bat in Queensland.
Queensland's chief biosecurity officer Jim Thompson said the property, on the Southern Downs region bordering neighbouring New South Wales state, had been quarantined and the remaining 20 horses would be tested for ABLV.
Young said rabies immunoglobulin and four doses of the rabies vaccine had proven effective against lyssavirus as a preventative treatment for people not showing any symptoms.
Local hospitals would be providing that prophylactic course to anyone determined to have been in sufficiently close contact with the dead horse, she added.