Inhibiting autophagy does not impair the immune response to tumors during chemotherapy, revealed a research by Jayanta Debnath at UCSF.
Inhibiting autophagy does not impair the immune response to tumors during chemotherapy, revealed a research by Jayanta Debnath at UCSF and published this week in the JCI. The findings provide support for the idea that combining autophagy inhibitors with certain chemotherapies may aid cancer treatment. Chemotherapies treat cancer by killing tumor cells, but certain types of chemotherapy can also drive an immune system response to target and destroy the remaining tumor cells. This immune targeting is elicited by molecules called damage-associated molecular patterns (DAMPS) that are released when a cell is killed.
‘Inhibiting autophagy may be a safe combinatorial treatment to enhance the cancer-killing effects of certain chemotherapies, revealed a new study.’
DAMPs are normally degraded in a process
called autophagy, and it has been suggested that limiting the
efficiency of autophagy could improve the efficacy of some
chemotherapies. However, because autophagy is also critical to other
aspects of immune system function, it is possible that inhibiting
autophagy could backfire and compromise chemotherapy-driven immune
targeting instead. In mouse models of cancer, treatment with autophagy inhibitors did not affect how immune cells targeted tumors during chemotherapy, in spite of other changes in general immune system function. These results suggest that inhibiting autophagy may be a safe combinatorial treatment to enhance the cancer-killing effects of certain chemotherapies.
Source-Eurekalert