About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Autophagy Inhibitors Could Improve Efficacy of Chemotherapies to Treat Cancer

by Dr. Trupti Shirole on October 26, 2016 at 4:53 PM
Font : A-A+

 Autophagy Inhibitors Could Improve Efficacy of Chemotherapies to Treat Cancer

Inhibiting autophagy does not impair the immune response to tumors during chemotherapy, revealed a research by Jayanta Debnath at UCSF and published this week in the JCI. The findings provide support for the idea that combining autophagy inhibitors with certain chemotherapies may aid cancer treatment.

Chemotherapies treat cancer by killing tumor cells, but certain types of chemotherapy can also drive an immune system response to target and destroy the remaining tumor cells. This immune targeting is elicited by molecules called damage-associated molecular patterns (DAMPS) that are released when a cell is killed.

Advertisement


DAMPs are normally degraded in a process called autophagy, and it has been suggested that limiting the efficiency of autophagy could improve the efficacy of some chemotherapies. However, because autophagy is also critical to other aspects of immune system function, it is possible that inhibiting autophagy could backfire and compromise chemotherapy-driven immune targeting instead.

In mouse models of cancer, treatment with autophagy inhibitors did not affect how immune cells targeted tumors during chemotherapy, in spite of other changes in general immune system function. These results suggest that inhibiting autophagy may be a safe combinatorial treatment to enhance the cancer-killing effects of certain chemotherapies.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
World AIDS Day 2022 - Equalize!
Test Your Knowledge on Sugar Intake and Oral Health
Test  Your Knowledge on Heart
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cancer and Homeopathy Cancer Facts Cancer Tattoos A Body Art Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant Autophagy: Self-Repair Mechanism at Cellular Level 

Most Popular on Medindia

Blood - Sugar Chart Turmeric Powder - Health Benefits, Uses & Side Effects Accident and Trauma Care A-Z Drug Brands in India Iron Intake Calculator Loram (2 mg) (Lorazepam) The Essence of Yoga Post-Nasal Drip Noscaphene (Noscapine) Vent Forte (Theophylline)
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Autophagy Inhibitors Could Improve Efficacy of Chemotherapies to Treat Cancer Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests