About My Health Careers Internship MedBlogs Contact us
Medindia
LOGIN REGISTER
Advertisement

Autism's Behavioral Symptoms may be Reversed by Under Trial Cancer Drug

by Kathy Jones on November 30, 2014 at 9:49 PM
Font : A-A+

 Autism's Behavioral Symptoms may be Reversed by Under Trial Cancer Drug

A drug undergoing test as a treatment for cancer could also help reverse autism's behavioral symptoms, says a new study.

Researchers from the University of Edinburgh and McGill University have identified a chemical pathway that goes awry in the brains of Fragile X patients, stated that a cancer drug candidate could reverse their behavioral symptoms and found that a naturally occurring anti-fungal called cercosporamide can block the pathway and improve sociability in mice with the condition.

Advertisement

The team identified a key molecule - eIF4E - that drives excess protein production in the brains of Fragile X patients. This can cause behavioural symptoms that include learning difficulties. It can also lead to more serious intellectual disabilities, delays in speech and language development and problems with social interactions.

The team found that treatment with cercosporamide blocks the activity of eIF4E, and therefore reduces the amounts of MMP-9, and reverses the behavioural symptoms in mice with a version of Fragile X Syndrome. The new findings suggested that it could have a use as a treatment for patients with Fragile X Syndrome.
Advertisement

Christos Gkogkas, of the University of Edinburgh's Patrick Wild Centre for Research into Autism, Fragile X Syndrome and Intellectual Disabilities, said that by designing treatments that block just this pathway, it is hoped that they can limit the potential side-effects and develop therapies that are more efficient than general treatment approaches.

The study is published in the journal Cell Reports.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Emotional Healing
Psychosis Risk Related to Cat Parasite
Sedentary Behavior Precipitates Night-Time Hot Flashes
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Autism Cancer and Homeopathy Signature Drug Toxicity Cancer Facts Cancer Tattoos A Body Art Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant Immune Checkpoint Inhibitors for Cancer Treatment 

Recommended Reading
Autism
Autism is a neurodevelopmental disorder typically characterized by impaired social and ......
Rett Syndrome
Rett Syndrome is a neurological disorder that affects development. It mostly affects the girl ......
Common Lifestyle Habits that Cause Diseases
Cigarette smoking, unhealthy diets, overuse of alcohol, and physical inactivity are some of the most...
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Health Benefits of Dandelion Plant
What is dandelion? Dandelion greens are nutrition powerhouses with a wide range of health benefits. ...
Immune Checkpoint Inhibitors for Cancer Treatment
Immune checkpoint inhibitors are promising drugs to treat a variety of cancers and the FDA has appro...
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use