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Anti-Cancer Drugs May Help Prevent Genetic Causes of Intellectual Disabilities

by Julia Samuel on May 21, 2015 at 6:36 PM
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Anti-Cancer Drugs May Help Prevent Genetic Causes of Intellectual Disabilities

A new study published in Journal eLife reports that a class of anti-cancer drugs may be able to prevent brain disorders, including Down syndrome and Fragile X syndrome.

Down syndrome and Fragile X are the two most prevalent genetic causes of intellectual disabilities. An extra copy of chromosome 21 causes down syndrome, while Fragile X is caused by a mutation in a single gene.

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In a series of experiments outlined in the study, the researchers showed that the Dscam protein activates another protein known as Abelson tyrosine kinase (Abl).

The scientists then took genetically modified flies that produced high levels of Dscam and gave them the cancer drug, which acts by blocking the action of Abl.
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The researcher found that giving the leukemia drugs nilotinib or bafetinib to fly larvae with Fragile X-like symptoms prevented the wild overgrowth of cell problems associated with the disorder.

"This study proposes a potential therapeutic approach for treating brain disorders associated with deregulated expression of the Dscam protein, which is seen in both Down syndrome and Fragile X syndrome," said senior study author Bing Ye from University of Michigan in the US.

"Although there is an amazing amount of similarity between flies and humans, more study is needed before we'll know if this could be a safe and effective treatment for human patients," Ye noted.

Source: Medindia
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