About Careers MedBlog Contact us

Analyzing Mouth Bacteria can Predict Hospitalizations in Liver Cirrhosis Patients

by Dr. Trupti Shirole on April 22, 2015 at 7:45 AM
Font : A-A+

 Analyzing Mouth Bacteria can Predict Hospitalizations in Liver Cirrhosis Patients

Liver cirrhosis is a slowly progressing disease in which healthy liver tissue is replaced with scar tissue, eventually preventing the liver from functioning properly. Hospitalization may be required in severe cases of liver damage. Analyzing the ratio of good-bad bacteria in the gut could help doctors predict which liver cirrhosis patients would suffer inflammations and require hospitalization. Now a new study has revealed that this prediction could be done even by analyzing the good-bad bacteria in saliva.

Dr. Jasmohan Bajaj, associate professor of hepatology at the Virginia Commonwealth University (VCU) School of Medicine in the US, said, "It has been believed that most of the pathogenesis of cirrhosis starts in the gut, which is what makes this discovery so fascinating. The fact that saliva, along with fluid in the gut, can be an indicator of inflammation tells us that we need to further explore the oral cavity and its connections to liver disease."


The study comprised of more than 100 cirrhosis patients, 38 of which had to be hospitalized within 90 days because of flare-ups. Researchers found that the ratio of good-to-bad microbes was similar in the saliva as in the stool of these patients who required hospitalization. The study also found that people with cirrhosis had impaired salivary defenses, mirroring the immune deficiencies that take place in the gut.

Co-author of the paper Phillip Hylemon, who is also from the VCU School of Medicine, said, "The data suggest that there may be a change in the overall mucosal-immune interface in cirrhosis patients, allowing a more toxic microbiota to emerge in both the gut and oral cavity."

The study will be published in Hepatology.

Source: Medindia


Recommended Reading

Latest Research News

Frozen Frontier: Humans Leave a Unique Microbial Mark on Mount Everest
Located at the South Col, the rocky area between Mount Everest and Lhotse serves as the final campsite for climbers as well as a frozen legacy of hardy microbes.
How Does Protein Synthesis in Diarrhea Causing Parasite Work?
The new finding is found to be valuable for screening specific medications and treatment against Giardia and other protozoan parasites.
Unlocking the Potential of CRISPR for Reversing Vision Loss
New CRISPR genome-editing strategy was found to have a positive impact in the treatment of inherited retinal diseases such as retinitis pigmentosa.
 New RT-qPCR Kit Detects Influenza, COVID-19
H3N2 Influenza: The newly developed RT-qPCR Kit to identify influenza, COVID-19 and respiratory virus has got approval from ICMR.
 Rheumatoid Arthritis: Does Taking Sex Hormones Help Women?
Does hormone replacement therapy help rheumatoid arthritis? Yes, the use of exogenous sex hormones is associated with remission in perimenopausal female patients.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Analyzing Mouth Bacteria can Predict Hospitalizations in Liver Cirrhosis Patients Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests