Alzheimer’s Risk Gene May Worsen Neurological Effects of Air Pollution in Children

Children carrying the APOE gene which is also a risk gene for Alzheimer's may be vulnerable to the damaging effects of air pollutants on the brain.

Children who carry APOE gene when exposed to air pollution may adversely affect the cognitive and behavioral development in children, reports a new study. The findings of the study are published in the journal Environmental Health Perspectives.

Previous studies carried out within the framework of the BREATHE project have linked childhood exposure to air pollution with diminished cognitive development, increased behavioral problems, and even structural differences in the brains of the children studied.

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‘APOE ε4 is the genetic risk factor for Alzheimer's disease. Children who carry APOE4 gene may be especially vulnerable to the harmful effects of air pollutants on the brain.’

In the new study, which analyzed data from over 1,600 children attending 39 schools in Barcelona, scientists observed that the association between exposure to traffic-related pollution and adverse effects on neurodevelopment was more marked in the children who carried the ε4 allele of the APOE gene.

Carriers of this genetic variant had higher behavior problem scores, and their attention capacity developed more slowly. Moreover, the volume of the caudate nucleus, an anatomical brain structure, tended to be smaller in that population.

"These findings suggest that children who carry this allele could be more vulnerable to the detrimental effects that air pollution has on important aspects of their neurodevelopment," explained Silvia Alemany, ISGlobal researcher and lead author of the study.

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"Systemic inflammation and oxidative stress are two of the most well-established mechanisms underlying the adverse health effects of air pollution. Interestingly, both of these mechanisms are also involved in the pathogenesis of dementia. Research has demonstrated an association between exposure to air pollution and cognitive impairment in older people. All these considerations and the fact that APOE ε4 is the most important known genetic risk factor for Alzheimer's disease led us to wonder whether the allele might also have a relationship with the adverse effects air pollution has on brain function in children," says Silvia Alemany.

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Genetic data were available for all of the participants. Tests were carried out to evaluate cognitive functions, behavioral problems and possible symptoms of attention deficit hyperactivity disorder. Traffic-related air pollution levels were calculated by actual measurements. Magnetic resonance imaging data were available for 163 of the study participants.

"More research will be needed in other populations to replicate these results, and we need to establish whether this possible genetic vulnerability also applies to exposure to air pollution during earlier stages of development, for example, in the prenatal period," warns ISGlobal researcher Jordi Sunyer, director of the BREATHE project.

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"In any case, once again the findings are clear: it is essential to implement measures to reduce traffic in the urban environment and, particularly, in places where children are present, such as the areas around schools.".

Source-Eurekalert