About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Alzheimer's Gene Carriers Have Higher Risk of Postoperative Delirium

by Medindia Content Team on August 25, 2007 at 3:28 PM
Font : A-A+

Alzheimer's Gene Carriers  Have Higher Risk of  Postoperative Delirium

Elderly patients who carry a gene associated with an increased risk of Alzheimer's disease and dementia have higher rates of postoperative delirium after major surgery.

The September issue of the journal Anesthesiology features a study linking the apolipoprotein E (APOE) e4 gene variant to the risk of postoperative delirium, a common postoperative complication in elderly patients.

Advertisement

"Our study showed that APOE e4 carrier status was associated with an increased risk for early postoperative delirium, after controlling for known demographic and clinical risk factors," says Dr. Jacqueline M. Leung of University of California, San Francisco.

The study included 190 elderly patients, average age 72.5 years, undergoing major surgery (other than heart surgery). A standard assessment was used to test for confusion and other symptoms of delirium. In addition, DNA samples were obtained to determine whether patients were carriers of the APOE e4 gene, which has been linked to an increased risk of late-onset Alzheimer's disease.
Advertisement

About 15 percent of patients had symptoms of postoperative delirium on the first and second days after surgery. On DNA analysis, 24 percent of patients were APOE e4 gene carriers.

Patients with APOE e4 had a higher rate of postoperative delirium: about 28 percent, compared to 11 percent of those who did not carry the APOE e4 gene. After adjustment for other risk factors—including older age, change in postoperative pain levels, and previous central nervous system disorders—patients who had at least one copy of the APOE e4 variant gene were nearly four times more likely to develop postoperative delirium.

Postoperative delirium is a relatively common side effect in elderly patients undergoing major surgery. A potentially prolonged and disabling problem, postoperative delirium has been linked to increased rates of nursing home placement and in-hospital death.

"Despite this prevalence and clinical importance, no specific causative factor has been identified," according to Dr. Leung.

Previous population studies have suggested that the APOE e4 gene variant is associated with increased rates of dementia, including the late-onset form of Alzheimer's disease (developing after age 65), and cognitive decline. (Other genes, but not APOE e4, have been linked to an increased risk of early-onset Alzheimer's disease.)

The new study suggests that APOE e4 may be a genetic risk factor for postoperative delirium. "This research is important in that it is one of the first studies in a large group of patients to investigate if there is a genetic predisposition to postoperative delirium," says Dr. Leung.

"Our results suggest that genetic predisposition plays a role, and may interact with anesthetic/surgical factors contributing to the development of early postoperative delirium," Dr. Leung adds. Further studies will be needed to determine how APOE e4 leads to an increased risk of postoperative delirium, including possible interactions with other risk factors. Another key question will be whether APOE e4 carriers who develop postoperative delirium are at increased risk for later cognitive impairment.

Source: Newswise
JAY/B
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
First Dose of COVID-19 Vaccines May Improve Mental Health
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Alzheimers Disease DNA Finger Printing Iodine Deficiency Disorder Creutzfeldt-Jakob Disease Diet and Alzheimer´s Disease Genetics of Alzheimer´s disease 

Recommended Reading
Alzheimers Disease
Alzheimer's disease is a progressive neurodegenerative disease affecting memory and thinking and ......
Creutzfeldt-Jakob Disease
Creutzfeldt-Jakob disease (CJD) is a rare form of degenerative brain disorder, or brain damage that ...
Diet and Alzheimer´s Disease
Alzheimer''s begins with forgetfulness, but over time affects speech and coordination along with dra...
DNA Finger Printing
DNA fingerprinting is a technique which helps forensic scientists and legal experts solve crimes, id...
Genetics of Alzheimer´s disease
There are numerous genes that have been discovered that are associated with Alzheimer’s disease and ...
Iodine Deficiency Disorder
To control IDD, the ‘National Goiter Control Program (NGCP)’ was launched which was later renamed as...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use