About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Alterations in Gene Can Prevent Non-Inheritable Parkinson's Disease and Dementia

by Reshma Anand on October 12, 2015 at 2:10 PM
Font : A-A+

Alterations in Gene Can Prevent Non-Inheritable Parkinson's Disease and Dementia

Functional changes in an immune regulating gene can prevent Parkinson's disease (PD) and dementia, revealed a new study.

Research team at University of Copenhagen, Denmark, has discovered that non-inheritable Parkinson's disease may be caused by functional changes in the immune regulating gene Interferon-beta (IFNbeta). Treatment with IFNbeta-gene therapy successfully prevented neuronal death and disease effects in an experimental model of PD. The results have just been published in prestigious scientific journal Cell.

Advertisement

The human brain consists of approximately 100 billion neurons, which coordinate activities in all parts of the body. The group of Professor Shohreh Issazadeh-Navikas has discovered that the immune gene IFNbeta plays a vital role in keeping neurons healthy.

Researchers found that IFNbeta is essential for neurons ability to recycle waste proteins. Without this, the waste proteins accumulate in disease-associated structures called Lewy bodies and with time the neurons die, explains first author Patrick Ejlerskov.
Advertisement

The research team found that mice missing IFNbeta developed Lewy bodies in parts of the brain, which control body movement and restoration of memory, and as a result they developed disease and clinical signs similar to patients with PD and dementia with Lewy bodies (DLB).

"Our hope is that this knowledge will enable development of more effective treatment of PD," says Professor Shohreh Issazadeh-Navikas.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Organ Donation Week 2022 - 'Take the Pledge to Save Lives'
Test your Knowledge on Heart Transplantation
Test Your Knowledge on Lung Transplantation
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
DNA Finger Printing Weaver Syndrome Dementia Vascular Dementia 

Most Popular on Medindia

Color Blindness Calculator Selfie Addiction Calculator Drug Interaction Checker Pregnancy Confirmation Calculator Iron Intake Calculator Loram (2 mg) (Lorazepam) Drug Side Effects Calculator Hearing Loss Calculator Sinopril (2mg) (Lacidipine) Calculate Ideal Weight for Infants
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use