About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Alteration in Drug Regimen Brings New Hope in Advanced Breast Cancer

by Savitha C Muppala on August 2, 2012 at 10:43 PM
Font : A-A+

 Alteration in Drug Regimen Brings New Hope in Advanced Breast Cancer

Advertisement
A study co-authored by a Loyola researcher and published in the New England Journal of Medicine is offering new hope to women with advanced breast cancer.The study found that combing two drugs that normally are each given as single agents significantly extended the lives of women with metastatic breast cancer. Kathy Albain, MD, a breast cancer specialist at Loyola University Medical Center, is among the main authors of the study.The study found that women who initially took the drugs anastrozole and fulvestrant at the same time together lived more than six months longer than women who took anastrozole alone, with fulvestrant given later when the disease progressed."This study is the first to show that combination hormonal therapy alone without chemotherapy improves survival in advanced breast cancer," Albain said. "This most likely will change the standard of care for how we treat these patients."First author is Rita Mehta, MD, of the University of California at Irvine.Anastrozole (brand name, Arimidex®) is a pill that is taken daily. It is in a class of medications called aromatase inhibitors. It works by decreasing the amount of estrogen the body makes. (Estrogen fuels breast cancer.) Fulvestrant (brand name Faslodex®) is given by injection. It binds to estrogen receptors, thereby blocking the effect estrogen has on cancer cells.The study included 707 postmenopausal women who had metastatic breast cancer that was hormone-receptor-positive. About half the women were randomly assigned to receive the standard regimen: treat first with anastrozole, and after the disease progresses, switch to fulvestrant. The other half were randomly assigned to receive anastrozole and fulvestrant in combination.Women who received the standard regimen survived a median of 41.3 months. Women who received the two drugs in combination survived a median of 47.7 months.Among women who received the standard regimen, it took a median of 13.5 months for the disease to progress. Among those who received the drugs in combination, it took 15 months before the disease progressed.The combination treatment produced even greater benefits among women who had not previously taken tamoxifen.Side effects generally were similar in both treatment groups, although only the combination group experienced the most severe side effects (one stroke and two pulmonary embolisms).

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Organ Donation Week 2022 - 'Take the Pledge to Save Lives'
Test your Knowledge on Heart Transplantation
Test Your Knowledge on Lung Transplantation
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Women and Cancer Drug Toxicity Pagets disease of the breast Mastitis Cancer and Homeopathy Signature Drug Toxicity Breast Cancer Facts Cancer Facts Cancer Tattoos A Body Art 

Most Popular on Medindia

Pregnancy Confirmation Calculator Noscaphene (Noscapine) Blood Pressure Calculator Color Blindness Calculator Calculate Ideal Weight for Infants Post-Nasal Drip Vent Forte (Theophylline) Nutam (400mg) (Piracetam) Sanatogen Blood - Sugar Chart
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use