Over-activity of the enzyme HDAC6 in the nerve ends exacerbates the symptoms of the neurogenerative condition Amyotrophic Lateral Sclerosis (ALS-Lou Gehrig's disease), demonstrated in fruit-flies by scientists at VIB and KY Leuven. Inhibition of this enzyme could offer a protective effect against ALS. Patrik Verstreken (VIB/KU Leuven): "Nobody wants to suffer from a degenerative condition such as amyotrophic lateral sclerosis (ALS), in which you lose coordination of all muscles through gradual damage to the nerve cells. ALS patients are conscious throughout the disease process, including death by suffocation. Any additional insight into the dysfunction of nerve cells and the defective transmission of signals to the muscles paves the way to further targeted ALS research." Amyotrophic Lateral Sclerosis - a degenerative process In patients with ALS, the nerve cells that allow for the synaptic transmission die off. Synaptic transmission is the transmission of signals to the muscles, which is essential for the coordination of the muscles. ALS falls under the collective term of neurodegenerative conditions, which includes diseases such as Parkinson's disease. It is a progressive, debilitating neurological disease for which there is currently no treatment available. ALS patients are very aware of the entire process. ALS patients often opt for euthanasia in order to avoid suffocating to death as the respiratory muscles also fail in the end. Over-activity HDAC6 Katarzyna Miskiewicz, Liya Jose and Patrik Verstreken have studied how this type of nerve cell becomes defective in fruit-flies that express a form of ALS. Fruit-flies are a very suitable model organism for neurological research. In the case of ALS, the specific defect is located at the nerve endings, where the investigators discovered an over-activity of the enzyme HDAC6. This over-activity of HDAC6 is a cause of the disrupted synaptic transmission, resulting in a symptomatic exacerbation of the disease. In order to stop this process, it would - in theory - be helpful to combat the over-activation of the enzyme HDAC6 in order to return to "normal" activity of the HDAC6 enzyme. Not only HDAC6 defect Although this discovery may provide a possible avenue for symptomatic ALS treatment, it should be noted that the HDAC6 defect is probably one of the many enzyme defects that play a role in ALS. Previously, Patrik Verstreken and Wim Robberecht (VIB/KU Leuven) demonstrated that another enzyme that is involved in ALS - Elp3 - acts on the same process at the nerve endings as HDAC6. Ideally, the various avenues should all be studied in the hope of finding a treatment for ALS in the future. Source: Eurekalert << Vascular Health in Indigenous Australians Improved by Treat... Tinnitus Patients Undergo Different Emotional Processing Sys... >> Recommended Reading Amyotrophic Lateral Sclerosis (ALS) Find out more about the degenerative disease- Amyotrophic lateral sclerosis. READ MORE Amyotrophic Lateral Sclerosis - New Findings Pluripotent stem cells derived from patients with ALS sheds light on how reduced levels of a specific protein may play a key role in causing inherited ALS. READ MORE Development In The Relief Of Spasms Related To Amyotrophic Lateral Sclerosis A neurodegenerative disease, Amyotrophic lateral sclerosis (ALS) has come with an occurrence rate in France similar to multiple sclerosis (two to three new cases per year for every 100,000 residents). READ MORE Amyotrophic Lateral Sclerosis Causing Gene Identified By means of new sequencing method, researchers have discovered a gene that appears to cause the occurrence of amyotrophic lateral sclerosis (ALS). READ MORE Food Preservatives - How Safe Are They? Food preservatives are basically antimicrobials or anti-oxidants that help preserve food by destroying the microbes and stopping decomposition of food products. READ MORE Most Popular on Medindia Blood Donation - Recipients Diaphragmatic Hernia Blood Pressure Calculator More News on: Amyotrophic Lateral Sclerosis (ALS)Food Preservatives - How Safe Are They?