Stroke is the fifth leading cause of death in the United States. Adults with gum disease (periodontal disease) may be at greater ischemic
stroke risk, according to research presented at the American Stroke
Association's International Stroke Conference 2017.
Researchers assessed 6,711 adults, who had not had a stroke, for
periodontal disease and categorized the adults according to whether they
had mild, moderate or severe periodontal disease. They followed
patients for 15 years for the incidence of stroke, also documenting the
stroke subtype based on cause.
‘Increasing levels of periodontal disease and stroke risk was most pronounced in the cardioembolic and thrombotic stroke subtypes.’
A total of 299 ischemic strokes occurred during the 15 years,
including 47% that were thrombotic stroke, from a clot within the
brain's blood vessels; 26% that were cardioembolic, when a blood
clot forms in the heart; and 20% that were lacunar strokes,
which occurs when there is a blockage of small arteries that supply
blood to the brain.
Participants with mild periodontal disease were 1.9 times more
likely to have an ischemic stroke than those without periodontal
disease. Those with moderate periodontal disease had 2.1 times higher
ischemic stroke risk and adults with severe gum disease were 2.2 times
more likely to suffer an ischemic stroke than those who had no
The association between increasing levels of periodontal disease
and stroke risk was most pronounced in the cardioembolic and thrombotic
The graded association between the level of gum disease and
incident ischemic stroke, supports a possible causal association between
gum disease and ischemic stroke, researchers said.