About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Adult Stem Cells That can Be Used for Treating Muscle Injuries Identified

by VR Sreeraman on September 5, 2007 at 6:21 PM
Font : A-A+

Adult Stem Cells That can Be Used for Treating Muscle Injuries Identified

A team of researchers have discovered a unique set of adult stem cells obtained from human muscle that can be used for treating muscle injuries.

The stem cells may also help treat diseases like heart attack and muscular dystrophy. The team from Children's Hospital of Pittsburgh of UPMC led by Johnny Huard, PhD, and Bruno Péault, PhD , isolated and characterized stem cells derived from blood vessels (known as myoendothelial cells).

Advertisement

The blood vessels can be easily isolated using cell-sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage cells.

'These characteristics may make them ideally suited as a potential therapy for muscle injuries and diseases,' according to Drs. Huard and Péault.
Advertisement

"Finding this population of stem cells in a human source represents a major breakthrough for us because it brings us much closer to a clinical application of this therapy," said Dr. Huard, the Henry J. Mankin Professor and vice chair for Research in the Department of Orthopaedic Surgery at the University of Pittsburgh School of Medicine.

"To make this available as a therapy, we would take a muscle biopsy from a patient with a muscle injury or disease, remove the myoendothelial cells and treat the cells in the lab. The stem cells would then be re-injected into the patient to repair the muscle damage. Because this is an autologous transplant, meaning from the patient to himself, there is not the risk of rejection you would have if you took the stem cells from another source," Dr Huard added.

Working in dystrophic mice while searching for a cure for Duchenne muscular dystrophy (DMD), Dr. Huard's laboratory team first identified a unique population of muscle-derived stem cells with the ability to repair muscle 8 years ago.

Dr. Péault, a professor in the Department of Pediatrics, Cell Biology and Physiology at the University of Pittsburgh School of Medicine, recognized the importance of determining the origin of these muscle-derived stem cells. His team applied, among others, techniques of confocal microscopy and cell sorting by flow cytometry which led to the discovery in human muscle biopsies that these myoendothelial cells are located adjacent to the walls of blood vessels.

According to their study, myoendothelial cells taken from the blood vessels are much more efficient at forming muscle than other sources of stem cells known as satellite and endothelial cells.

A thousand myoendothelial cells transplanted into the injured skeletal muscle of immuno-deficient mice produced, on average, 89 muscle fibres, compared with 9 and 5 muscle fibres for endothelial and satellite cells, respectively. Myoendothelial cells also showed no propensity to form tumours, a concern with other stem cell therapies.

Drs. Huard, Péault and colleagues in Children's Stem Cell Research Center (SCRC) are researching and developing numerous therapeutic uses for the population of stem cells the SCRC team identified. One of the most promising uses could be for the treatment of DMD, a genetic disease estimated to affect one in every 3,500 boys. Patients with DMD lack dystrophin, a protein that gives muscle cells structure.

Dr. Huard is an internationally recognized cell biologist conducting laboratory research into the therapeutic use of stem cells to treat a variety of musculoskeletal and orthopaedic diseases and injuries. In the lab, Dr. Huard is developing cutting-edge therapies to regenerate bone and cartilage and to repair damaged muscle. The application of these therapies could range from the repair of heart muscle damaged by heart attack to the repair of sports-related bone, cartilage and muscle injuries.

Dr. Péault is internationally recognized principally for his work on the prospective identification and characterization of human hematopoietic (blood) stem cells, of which his laboratory has also deciphered the ultimate origin during embryonic life. Besides blood development, his team also is investigating elusive populations of multipotent stem cells that persist in adult tissues, including dispensable ones like fat. Such cells should be invaluable for the regenerative therapy of multiple organs damaged by trauma, aging, genetic or acquired diseases.

Results of the study are published in the September issue of the journal Nature Biotechnology.

Source: ANI
LIN/C
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Cervical Cancer Awareness Month 2022
Ultra-Low-Fat Diet
Goji Berries May Protect Against Age-Related Vision Loss
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Stem Cells - Cord Blood Stem Cells - Fundamentals Parkinsons Disease Surgical Treatment Genetics and Stem Cells Bone Marrow Transplantation Tissue Engineering and Regenerative Medicine Stem Cells Leg Injuries and Disorders Stem Cell Therapy 

Recommended Reading
Muscular Dystrophy
Overview about muscular dystrophy, a muscle disease characterized by muscle weakness and muscle ......
Stem Cells - Fundamentals
Encyclopedia section of medindia gives general info about Stem Cells...
Stem Cells may Repair the Damage Caused by Heart Attacks
A new study is employing stem cells to repair heart attack damages. The study is being conducted by ...
Bone Marrow Transplantation
Preferred Term is Hematopoietic stem cell transplantation. In this stem cell from bone marrow are in...
Leg Injuries and Disorders
Legs are easily prone to injuries while playing sports, running or falling. These injuries affect th...
Stem Cell Therapy
Stem cell therapy or regenerative medicine uses undifferentiated cells for the treatment of conditio...
Stem Cells - Cord Blood
Encyclopedia section of medindia gives general info about Cord Blood...
Tissue Engineering and Regenerative Medicine
This new field is an amalgamation of biology, medicine and engineering, and is believed to have mind...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT A DOCTOR
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)