About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Activation of Signal-Regulated Kinase 1/2 Exhibits Protective Effect on Neuronal Injury

by Bidita Debnath on July 11, 2014 at 12:26 AM
Font : A-A+

 Activation of Signal-Regulated Kinase 1/2 Exhibits Protective Effect on Neuronal Injury

In acute cerebral ischemia, activation of extracellular signal-regulated kinase 1/2 has been demonstrated.

Yaning Zhao and her colleagues, Hebei United University, China induced transient whole-brain ischemia by four-vessel occlusion in normal and diabetic rats and intravenously injected diabetic rats with extracellular signal-regulated kinase 1/2 30 minutes before ischemia as a pretreatment.

Advertisement

Results showed that during the pathological progression of cerebral ischemia/reperfusion in rats, activation of extracellular signal-regulated kinase 1/2 exhibits protective effect on neuronal injury.

Reduced extracellular signal-regulated kinase 1/2 decreases Ku70 activity, increases Bax expression and thereby increases the number of lost hippocampal neurons in diabetic rats after cerebral ischemia/reperfusion. These results were published in Neural Regeneration Research (Vol. 9, No. 7, 2014).

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Health Benefits of Sea Buckthorn
Contraceptive Pills in Polycystic Ovary Syndrome (PCOS) Curtail Type 2 Diabetes Risk
Mushroom May Help Cut Down the Odds of Developing Depression
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Athletes Foot 

Recommended Reading
After Chronic Cerebral Ischemia, 3-N-Butylphthalide Improves Neuronal Morphology
The pathogenesis of vascular dementia induced by chronic cerebral ischemia is complex, mainly ......
Treating Cerebral Ischemia
For treating cerebral ischemia/reperfusion, mesenchymal stem cell transplantation is a novel means ....
Tau Protein Phosphorylation in Rats Subjected to Cerebral Ischemia-reperfusion Injury
Hyperphosphorylation of the microtu-bule-associated protein tau induced by transient brain ......
Research Explores Use of Salvianolate for Treatment of Cerebral Ischemia-Reperfusion Injuries
Previous research has shown that salvianolic acid B is a phenolic acid compound composed of three .....
Athletes Foot
Athlete’s foot (tinea pedis/ringworm of the foot) is a fungal infection of the feet....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use