The pathogenesis of vascular dementia induced by chronic cerebral ischemia is complex, mainly consisting of oxidative stress injury, energy metabolism disorder, cholinergic nerve dysfunction and neuronal apoptotic cell death.
There is evidence that 3-n-butylphthalide can effectively antagonize acute ischemic stroke. However, the effect of 3-n-butylphthalide on chronic ischemic stroke remains unclear.
Dr. Wanhong Zhao and her team, Institute of Basic Medical Sciences, Hubei University of Medicine, China performed a study and found that 3-n-butylphthalide improved neuronal morphology in cerebral cortex and hippocampus, alleviated oxidative stress caused by chronic cerebral ischemia, improved cholinergic function, and inhibited amyloid beta accumulation in rats subjected to chronic cerebral ischemia.
Their findings were published in Neural Regeneration Research
(Vol. 9, No. 7, 2014).