Vinflunine is available in an injection form which should be given intravenously or deep into the vein slowly over 20 minutes.
Vinflunine intravenous infusion should be given only by a trained health care provider who must use gloves, goggles, and protective clothing while handling the dilution and administration.
Do not push or administer as a rapid intravenous infusion and also never give through the spine as an intrathecal injection as it can cause harm to the patient resulting in neurotoxicity.
The required volume of vinflunine is withdrawn from the vial and diluted with 250 ml of 0.9% sodium chloride or 5% dextrose solution only in a clean and non-contaminated area preferably using aseptic techniques. The diluted solution should be used immediately.
Once the infusion is completed flush the IV line with the remaining 250 ml of 0.9% sodium chloride or 5 % dextrose solution.
The recommended adult dose of vinflunine is 320 mg/m2 that should be given every three weeks.
Dose adjustments can be made depending on the occurrence of side effects caused during the treatment with vinflunine.
Similarly, the treatment with vinflunine should be temporarily stopped or permanently discontinued if the toxicity or side effects are severe.
• If there is an allergy to vinflunine
• Pregnancy and breastfeeding
• Immunization with live viral vaccines (e.g., MMR, Yellow fever)
• History of active infection (e.g., Tuberculosis)
• Undergoing treatment for infertility
Vinflunine intravenous infusion should be given only by a trained health care provider who must use gloves, goggles, and protective clothing while handling the dilution and administration.
Do not push or administer as a rapid intravenous infusion and also never give through the spine as an intrathecal injection as it can cause harm to the patient resulting in neurotoxicity.
The required volume of vinflunine is withdrawn from the vial and diluted with 250 ml of 0.9% sodium chloride or 5% dextrose solution only in a clean and non-contaminated area preferably using aseptic techniques. The diluted solution should be used immediately.
Once the infusion is completed flush the IV line with the remaining 250 ml of 0.9% sodium chloride or 5 % dextrose solution.
Dosage & When it is to be taken
The dose of vinflunine is calculated based on the patient’s body surface area (BSA) taking into consideration the height and the weight of the patient before prescribing vinflunine.The recommended adult dose of vinflunine is 320 mg/m2 that should be given every three weeks.
Dose adjustments can be made depending on the occurrence of side effects caused during the treatment with vinflunine.
Similarly, the treatment with vinflunine should be temporarily stopped or permanently discontinued if the toxicity or side effects are severe.
When it is not to be taken (Contraindications)
Vinflunine should not be used in patients-• If there is an allergy to vinflunine
• Pregnancy and breastfeeding
• Immunization with live viral vaccines (e.g., MMR, Yellow fever)
• History of active infection (e.g., Tuberculosis)
• Undergoing treatment for infertility
