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Irinotecan Interaction with other Drugs


Irinotecan is an antineoplastic agent, prescribed for colon or rectal cancer, either alone or in combination with other medications.

Irinotecan Interaction with 191 drugs. Find out more in the list below:

Acetyl Sulfisoxazole


The metabolism of Irinotecan can be decreased when combined with Acetyl sulfisoxazole.

Acetyldigitoxin


Acetyldigitoxin may decrease the cardiotoxic activities of Irinotecan.

Adenine


The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Adenine.

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Amiodarone


The serum concentration of Irinotecan can be increased when it is combined with Amiodarone.

Ancestim


The risk or severity of cytotoxicity can be increased when Ancestim is combined with Irinotecan.

Anhydrous Tacrolimus


Tacrolimus may increase the immunosuppressive activities of Irinotecan.

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Anthrax immune globulin, human


The risk or severity of adverse effects can be increased when Irinotecan is combined with Anthrax immune globulin human.

Apalutamide


The serum concentration of Irinotecan can be decreased when it is combined with Apalutamide.

Aprepitant


The serum concentration of Irinotecan can be increased when it is combined with Aprepitant.

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Asunaprevir


The serum concentration of Asunaprevir can be increased when it is combined with Irinotecan.

Atazanavir


The serum concentration of Irinotecan can be increased when it is combined with Atazanavir.

Atomoxetine


The metabolism of Irinotecan can be decreased when combined with Atomoxetine.

Atorvastatin


The risk or severity of adverse effects can be increased when Irinotecan is combined with Atorvastatin.

BCG Vaccine


The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Irinotecan.

BCG, Live, Connaught Strain


The risk or severity of adverse effects can be increased when Irinotecan is combined with Bacillus calmette-guerin substrain connaught live antigen.

BCG, Live, Tice Strain


The risk or severity of adverse effects can be increased when Irinotecan is combined with Bacillus calmette-guerin substrain tice live antigen.

Bevacizumab


The risk or severity of adverse effects can be increased when Bevacizumab is combined with Irinotecan.

Bevacizumab-Awwb


The risk or severity of adverse effects can be increased when Bevacizumab is combined with Irinotecan.

Boceprevir


The serum concentration of Irinotecan can be increased when it is combined with Boceprevir.

Bortezomib


The metabolism of Irinotecan can be decreased when combined with Bortezomib.

Bosentan


The serum concentration of Irinotecan can be decreased when it is combined with Bosentan.

Bosentan Anhydrous


The serum concentration of Irinotecan can be decreased when it is combined with Bosentan.

Bosutinib


The serum concentration of Bosutinib can be increased when it is combined with Irinotecan.

Bosutinib monohydrate


The serum concentration of Bosutinib can be increased when it is combined with Irinotecan.

Bromocriptine


The risk or severity of adverse effects can be increased when Bromocriptine is combined with Irinotecan.

Cabazitaxel


The risk or severity of adverse effects can be increased when Cabazitaxel is combined with Irinotecan.

Cabergoline


The risk or severity of adverse effects can be increased when Cabergoline is combined with Irinotecan.

Carbamazepine


The serum concentration of Irinotecan can be decreased when it is combined with Carbamazepine.

Ceritinib


The serum concentration of Irinotecan can be increased when it is combined with Ceritinib.

Cerivastatin


The serum concentration of Cerivastatin can be increased when it is combined with Irinotecan.

Citalopram


The metabolism of Irinotecan can be decreased when combined with Citalopram.

Clarithromycin


The serum concentration of Irinotecan can be increased when it is combined with Clarithromycin.

Clemastine


The metabolism of Irinotecan can be decreased when combined with Clemastine.

Clopidogrel


The metabolism of Irinotecan can be decreased when combined with Clopidogrel.

Clotrimazole


The metabolism of Irinotecan can be decreased when combined with Clotrimazole.

Clozapine


The risk or severity of adverse effects can be increased when Irinotecan is combined with Clozapine.

Cobicistat


The serum concentration of Irinotecan can be increased when it is combined with Cobicistat.

Conivaptan


The serum concentration of Conivaptan can be increased when it is combined with Irinotecan.

Crizotinib


The metabolism of Irinotecan can be decreased when combined with Crizotinib.

Curcumin


The serum concentration of Irinotecan can be increased when it is combined with Curcumin.

Cyclophosphamide


Cyclophosphamide may increase the cardiotoxic activities of Irinotecan.

Cyclophosphamide Anhydrous


Cyclophosphamide may increase the cardiotoxic activities of Irinotecan.

Cyclosporine


The metabolism of Irinotecan can be decreased when combined with Cyclosporine.

Dabrafenib


The serum concentration of Irinotecan can be decreased when it is combined with Dabrafenib.

Darunavir


The serum concentration of Irinotecan can be increased when it is combined with Darunavir.

Dasatinib


The serum concentration of Irinotecan can be increased when it is combined with Dasatinib.

Dasatinib Anhydrous


The serum concentration of Irinotecan can be increased when it is combined with Dasatinib.

Deferasirox


The serum concentration of Irinotecan can be decreased when it is combined with Deferasirox.

Delavirdine


The metabolism of Irinotecan can be decreased when combined with Delavirdine.

Denosumab


The risk or severity of adverse effects can be increased when Denosumab is combined with Irinotecan.

Desipramine


The metabolism of Irinotecan can be decreased when combined with Desipramine.

Deslanoside


Deslanoside may decrease the cardiotoxic activities of Irinotecan.

Digitoxin


Digitoxin may decrease the cardiotoxic activities of Irinotecan.

Digoxin


Digoxin may decrease the cardiotoxic activities of Irinotecan.

Dihydroergocornine


The risk or severity of adverse effects can be increased when Dihydroergocornine is combined with Irinotecan.

Dihydroergocristine


The risk or severity of adverse effects can be increased when Dihydroergocristine is combined with Irinotecan.

Dihydroergotamine


The risk or severity of adverse effects can be increased when Dihydroergotamine is combined with Irinotecan.

Diltiazem


The metabolism of Irinotecan can be decreased when combined with Diltiazem.

Dipyrone


The risk or severity of myelosuppression can be increased when Metamizole is combined with Irinotecan.

Docetaxel


The risk or severity of adverse effects can be increased when Docetaxel is combined with Irinotecan.

DOCETAXEL ANHYDROUS


The risk or severity of adverse effects can be increased when Docetaxel is combined with Irinotecan.

Doxorubicin


The metabolism of Irinotecan can be decreased when combined with Doxorubicin.

Doxorubicin Hydrochloride


The metabolism of Irinotecan can be decreased when combined with Doxorubicin.

Doxycycline


The metabolism of Irinotecan can be decreased when combined with Doxycycline.

Doxycycline Anhydrous


The metabolism of Irinotecan can be decreased when combined with Doxycycline.

Dronedarone


The metabolism of Irinotecan can be decreased when combined with Dronedarone.

Eltrombopag


The serum concentration of Irinotecan can be increased when it is combined with Eltrombopag.

Enasidenib


The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Enasidenib.

Enzalutamide


The serum concentration of Irinotecan can be decreased when it is combined with Enzalutamide.

Ergonovine


The risk or severity of adverse effects can be increased when Ergonovine is combined with Irinotecan.

Ergotamine


The risk or severity of adverse effects can be increased when Ergotamine is combined with Irinotecan.

Erlotinib


The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Erlotinib.

Ertugliflozin


The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Ertugliflozin.

Erythromycin


The metabolism of Irinotecan can be decreased when combined with Erythromycin.

Fingolimod


Irinotecan may increase the immunosuppressive activities of Fingolimod.

Fluconazole


The metabolism of Irinotecan can be decreased when combined with Fluconazole.

Flunitrazepam


The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Flunitrazepam.

Fluvastatin


The serum concentration of Fluvastatin can be increased when it is combined with Irinotecan.

Fluvoxamine


The metabolism of Irinotecan can be decreased when combined with Fluvoxamine.

Fosamprenavir


The metabolism of Irinotecan can be decreased when combined with Fosamprenavir.

Fosaprepitant


The serum concentration of Irinotecan can be increased when it is combined with Fosaprepitant.

Fosphenytoin


The serum concentration of Irinotecan can be decreased when it is combined with Fosphenytoin.

Fostamatinib


The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Fostamatinib.

Fusidate


The serum concentration of Irinotecan can be increased when it is combined with Fusidic Acid.

Fusidic Acid


The serum concentration of Irinotecan can be increased when it is combined with Fusidic Acid.

Gemfibrozil


The serum concentration of the active metabolites of Irinotecan can be increased when Irinotecan is used in combination with Gemfibrozil.

Glecaprevir


The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Glecaprevir.

Hepatitis A Vaccine, Inactivated


The risk or severity of adverse effects can be increased when Irinotecan is combined with Hepatitis A Vaccine.

Hepatitis B Surface Antigen Vaccine


The risk or severity of adverse effects can be increased when Irinotecan is combined with Hepatitis B Vaccine (Recombinant).

Hypoxis hemerocallidea root extract


The therapeutic efficacy of Irinotecan can be decreased when used in combination with St. John's Wort.

Ibrutinib


The serum concentration of Ibrutinib can be increased when it is combined with Irinotecan.

Idelalisib


The serum concentration of Irinotecan can be increased when it is combined with Idelalisib.

Imatinib


The metabolism of Irinotecan can be decreased when combined with Imatinib.

Indinavir


The serum concentration of Irinotecan can be increased when it is combined with Indinavir.

INDINAVIR ANHYDROUS


The serum concentration of Irinotecan can be increased when it is combined with Indinavir.

Indomethacin


The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Indomethacin.

Isavuconazole


The serum concentration of Irinotecan can be increased when it is combined with Isavuconazole.

Isavuconazonium


The metabolism of Irinotecan can be decreased when combined with Isavuconazonium.

Isradipine


The metabolism of Irinotecan can be decreased when combined with Isradipine.

Itraconazole


The serum concentration of Irinotecan can be increased when it is combined with Itraconazole.

Ivacaftor


The serum concentration of Irinotecan can be increased when it is combined with Ivacaftor.

Ketoconazole


The serum concentration of Irinotecan can be increased when it is combined with Ketoconazole.

Leflunomide


The risk or severity of adverse effects can be increased when Irinotecan is combined with Leflunomide.

Lipegfilgrastim


Irinotecan may increase the myelosuppressive activities of Lipegfilgrastim.

Lisuride


The risk or severity of adverse effects can be increased when Lisuride is combined with Irinotecan.

Lopinavir


The serum concentration of Irinotecan can be increased when it is combined with Lopinavir.

Lovastatin


The serum concentration of Lovastatin can be increased when it is combined with Irinotecan.

Luliconazole


The serum concentration of Irinotecan can be increased when it is combined with Luliconazole.

Lumacaftor


The serum concentration of Irinotecan can be decreased when it is combined with Lumacaftor.

Metergoline


The risk or severity of adverse effects can be increased when Metergoline is combined with Irinotecan.

Methylergonovine


The risk or severity of adverse effects can be increased when Methylergometrine is combined with Irinotecan.

Methysergide


The risk or severity of adverse effects can be increased when Methysergide is combined with Irinotecan.

Mifepristone


The serum concentration of Irinotecan can be increased when it is combined with Mifepristone.

Mitotane


The serum concentration of Irinotecan can be decreased when it is combined with Mitotane.

Natalizumab


The risk or severity of adverse effects can be increased when Irinotecan is combined with Natalizumab.

Nefazodone


The serum concentration of Irinotecan can be increased when it is combined with Nefazodone.

Nelfinavir


The serum concentration of Irinotecan can be increased when it is combined with Nelfinavir.

Netupitant


The serum concentration of Irinotecan can be increased when it is combined with Netupitant.

Nevirapine


The serum concentration of Irinotecan can be decreased when it is combined with Nevirapine.

Nicergoline


The risk or severity of adverse effects can be increased when Nicergoline is combined with Irinotecan.

Nilotinib


The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Nilotinib.

Ocrelizumab


Ocrelizumab may increase the immunosuppressive activities of Irinotecan.

Olaparib


The metabolism of Irinotecan can be decreased when combined with Olaparib.

Osimertinib


The serum concentration of Irinotecan can be increased when it is combined with Osimertinib.

Ouabain


Ouabain may decrease the cardiotoxic activities of Irinotecan.

Ovine Digoxin Immune Fab


Digoxin Immune Fab (Ovine) may decrease the cardiotoxic activities of Irinotecan.

Paclitaxel


The risk or severity of adverse effects can be increased when Paclitaxel is combined with Irinotecan.

Palbociclib


The serum concentration of Irinotecan can be increased when it is combined with Palbociclib.

Paroxetine


The metabolism of Irinotecan can be decreased when combined with Paroxetine.

Pazopanib


The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Pazopanib.

Pentobarbital


The serum concentration of Irinotecan can be decreased when it is combined with Pentobarbital.

Pergolide


The risk or severity of adverse effects can be increased when Pergolide is combined with Irinotecan.

Phenobarbital


The serum concentration of Irinotecan can be decreased when it is combined with Phenobarbital.

Phenytoin


The serum concentration of Irinotecan can be decreased when it is combined with Phenytoin.

Pibrentasvir


The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Pibrentasvir.

Pimecrolimus


The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Irinotecan.

Pitavastatin


The serum concentration of Pitavastatin can be increased when it is combined with Irinotecan.

Posaconazole


The serum concentration of Irinotecan can be increased when it is combined with Posaconazole.

Pravastatin


The serum concentration of Pravastatin can be increased when it is combined with Irinotecan.

Primidone


The serum concentration of Irinotecan can be decreased when it is combined with Primidone.

Propofol


The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Propofol.

Proscillaridin


Proscillaridin may decrease the cardiotoxic activities of Irinotecan.

Quazepam


The serum concentration of Irinotecan can be increased when it is combined with Quazepam.

Rabies Immune Globulin, Human


The risk or severity of adverse effects can be increased when Irinotecan is combined with Human rabies virus immune globulin.

Rabies Virus Vaccine Flury-Lep Strain


The risk or severity of adverse effects can be increased when Irinotecan is combined with Rabies virus inactivated antigen, A.

Ranolazine


The serum concentration of Irinotecan can be increased when it is combined with Ranolazine.

Regorafenib


The serum concentration of the active metabolites of Irinotecan can be increased when Irinotecan is used in combination with Regorafenib.

Rifabutin


The serum concentration of Irinotecan can be decreased when it is combined with Rifabutin.

Rifampin


The serum concentration of Irinotecan can be decreased when it is combined with Rifampicin.

Rifapentine


The serum concentration of Irinotecan can be decreased when it is combined with Rifapentine.

Rilpivirine


The serum concentration of Rilpivirine can be increased when it is combined with Irinotecan.

Roflumilast


Roflumilast may increase the immunosuppressive activities of Irinotecan.

Rolapitant


The serum concentration of Irinotecan can be increased when it is combined with Rolapitant.

Rosuvastatin


The serum concentration of Rosuvastatin can be increased when it is combined with Irinotecan.

ROTAVIRUS VACCINE, LIVE


The risk or severity of adverse effects can be increased when Irinotecan is combined with Rotavirus Vaccine.

Rubella Virus Vaccine Live (wistar Ra 27-3 Strain)


The risk or severity of adverse effects can be increased when Irinotecan is combined with Rubella virus vaccine.

Rucaparib


The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Rucaparib.

Salmonella enterica subsp. enterica serovar typhi


The risk or severity of adverse effects can be increased when Irinotecan is combined with Salmonella typhi ty21a live antigen.

Saquinavir


The serum concentration of Irinotecan can be increased when it is combined with Saquinavir.

Saquinavir Mesylate


The serum concentration of Irinotecan can be increased when it is combined with Saquinavir.

Sarilumab


The therapeutic efficacy of Irinotecan can be decreased when used in combination with Sarilumab.

Sertraline


The metabolism of Irinotecan can be decreased when combined with Sertraline.

Sildenafil


The metabolism of Irinotecan can be decreased when combined with Sildenafil.

Siltuximab


The serum concentration of Irinotecan can be decreased when it is combined with Siltuximab.

Simeprevir


The serum concentration of Irinotecan can be increased when it is combined with Simeprevir.

Simvastatin


The serum concentration of Simvastatin can be increased when it is combined with Irinotecan.

sipuleucel-T


The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Irinotecan.

Sorafenib


The serum concentration of Irinotecan can be increased when it is combined with Sorafenib.

ST. JOHN'S WORT EXTRACT


The therapeutic efficacy of Irinotecan can be decreased when used in combination with St. John's Wort.

Sulfisoxazole


The metabolism of Irinotecan can be decreased when combined with Sulfisoxazole.

Tacrolimus


Tacrolimus may increase the immunosuppressive activities of Irinotecan.

Telaprevir


The serum concentration of Irinotecan can be increased when it is combined with Telaprevir.

Telithromycin


The serum concentration of Irinotecan can be increased when it is combined with Telithromycin.

Teriflunomide


The serum concentration of Irinotecan can be increased when it is combined with Teriflunomide.

Tetanus Toxoid Vaccine, Inactivated


The risk or severity of adverse effects can be increased when Irinotecan is combined with Clostridium tetani toxoid antigen (formaldehyde inactivated).

Thiotepa


The metabolism of Irinotecan can be decreased when combined with Thiotepa.

Ticlopidine


The metabolism of Irinotecan can be decreased when combined with Ticlopidine.

Tocilizumab


The serum concentration of Irinotecan can be decreased when it is combined with Tocilizumab.

Tofacitinib


Irinotecan may increase the immunosuppressive activities of Tofacitinib.

Tolvaptan


The serum concentration of Tolvaptan can be increased when it is combined with Irinotecan.

Trastuzumab


Trastuzumab may increase the cardiotoxic activities of Irinotecan.

Typhoid Vaccine Live Ty21a


The risk or severity of adverse effects can be increased when Irinotecan is combined with Salmonella typhi ty21a live antigen.

Typhoid Vi Polysaccharide Vaccine, S typhi Ty2 strain


The risk or severity of adverse effects can be increased when Irinotecan is combined with Salmonella typhi ty2 vi polysaccharide antigen.

Varicella Virus Vaccine Live (Oka-Merck) strain


The risk or severity of adverse effects can be increased when Irinotecan is combined with Varicella Zoster Vaccine (Live/Attenuated).

Vemurafenib


The serum concentration of Irinotecan can be increased when it is combined with Vemurafenib.

Venlafaxine


The metabolism of Irinotecan can be decreased when combined with Venlafaxine.

Verapamil


The metabolism of Irinotecan can be decreased when combined with Verapamil.

Voriconazole


The serum concentration of Irinotecan can be increased when it is combined with Voriconazole.

Yellow Fever Vaccine


The risk or severity of adverse effects can be increased when Irinotecan is combined with Yellow Fever Vaccine.

Yellow-Fever Virus Vaccine, 17D-204 strain


The risk or severity of adverse effects can be increased when Irinotecan is combined with Yellow Fever Vaccine.

Ziprasidone


The metabolism of Irinotecan can be decreased when combined with Ziprasidone.

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