Selinexor is an anticancer drug that is indicated for the treatment of adults with relapsed or refractory multiple myeloma (RRMM) in combination with dexamethasone.
Selinexor is an anticancer drug used for the treatment of adult patients with relapsed or refractory multiple myeloma (RRMM) in combination with dexamethasone.
Refractory multiple myeloma is a cancer of white blood cells that is not managed by treatment.
Initial dose of Selinexor is 80mg in combination with dexamethasone taken orally on Days 1 and 3 of each week.
Use dexamethasone is 20mg orally with each dose of Selinexor Available as Tablets: 20mg
Each dose of Selinexor should be taken at the same time of the day.
Swallow each tablet whole with water.
Do not chew, break, crush or spilt the tablets.
Patient should drink enough fluids to prevent dehydration and eat enough calories to prevent weight loss.
Duration for which selinexor will be taken is decided by healthcare provider according to the disease condition.
If a dose of Selinexor is delayed or missed then the patients should take the next dose at the regular scheduled time. In case a patient vomits a dose of Selinexor then do not repeat the dose and the next dose should be taken according to the regular schedule.
Side effects include thrombocytopenia(low platelet count), tiredness, nausea, anemia, decreased appetite, decreased weight, diarrhea, vomiting, low sodium levels, low white blood cell count, constipation, dyspnea, and upper respiratory tract infection
• Monitor platelet count and neutrophil count before and during treatment with Selinexor. The dose should be stopped or adjusted accordingly.
• Gastrointestinal symptoms like nausea, vomiting, weight loss, anorexia, and diarrhea can occur hence, antiemetics like aprepitant, dolasetron, ondansetron should be given before each dose. The dose should be stopped or adjusted according to the symptoms.
• Decreased sodium levels can occur during therapy hence, sodium levels should be monitored. Hyperglycemia and high serum paraprotein levels should be corrected.
• Signs and symptoms of infections should be monitored and treated.
• Do not take Selinexor with other medications likesilodosin, scopolamine, benazepril, antiepileptic drugs that can dizziness or confusion.
• Do not operate heavy machinery after taking Selinexor. To avoid dizziness or confusion, optimize hydration status, blood count and concomitant medications.
• Selinexor can cause fetal harm. Hence, females of reproductive potential should use effective contraception. Males with female partners who can get pregnant should use effective contraception.
• During treatment with Selinexor, inform your healthcare provider if bruising or bleeding occurs.
• Before taking Selinexor inform your healthcare provider about recent infections and bleeding problems.
• Patients should inform their doctors about all the medications they take including herbal medications, OTC products, and vitamin supplements.
Do not use with drugs like acrivastine, adalimumab, amiodarone, baclofen, buprenorphine, carbamazepine, ciprofloxacin, citalopram, diazepam, fluvoxamine, haloperidol, leflunomide, methadone, tramadol, etc.
Store Selinexor at or below 30°C (86°F).