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Protamine Sulphate - Indications, Dosage, Side Effects and Precautions

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Information about Protamine Sulphate

Generic Name : Protamine Sulphate
Up-to-date prescription details regarding Protamine Sulphate are provided here.

Pronunciation : PRO-tuh-meen SULL-fate

Learn the correct pronunciation of the Protamine Sulphate, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.
You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.


Therapeutic Classification : Heparin Antagonists

Trade Names/Brand Names of Protamine Sulphate

India :

International :


Protamine Sulfate

Why is Protamine Sulphate Prescribed? (Indications)

This medication is a heparin antagonist, prescribed for reversing the anticoagulant effects of heparin.

When should Protamine Sulphate not be taken? (Contraindications)

Hypersensitivity.

What is the dosage of Protamine Sulphate?

IV- 1 mg for each 90 units of heparin derived from lung tissue or 115 units of heparin derived from intestinal mucosa.

How should Protamine Sulphate be taken?

It comes as a solution for injection to be administered by a healthcare provider into the vein.

What are the warnings and precautions for Protamine Sulphate?

• Caution should be exercised in patients with history of poor blood circulation, heparin rebound, lung swelling, any allergy, children, during pregnancy and breastfeeding.

• Avoid too much rapid application.

• Monitor prothrombin time regularly while taking this medication.

What are the side effects of Protamine Sulphate?

Heart - Low blood pressure, slow heart rate, and circulatory collapse.
Central Nervous System - Lassitude.
Gastrointestinal - Nausea and vomiting.
Respiratory - Shortness of breath, lung swelling and acute pulmonary hypertension.
Miscellaneous - Severe respiratory distress, poor blood circulation, noncardiogenic lung swelling; transient flushing and feeling of warmth and back pain.

What are the other precautions for Protamine Sulphate?

Avoid excess dosage.

What are the storage conditions for Protamine Sulphate?

Store it at controlled room temperature (15 and 30°C). Do not freeze.
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