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General Information on Glycopyrrolate

Generic Name : Glycopyrrolate

Pronunciation : glye-koe-PYE-roe-late

Latest prescription information about Glycopyrrolate. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.

Other Name(s) of Glycopyrrolate

Glycopyrronium Bromide

Why is Glycopyrrolate Prescribed? (Indications)

This medication is a muscarinic anticholinergic agent, prescribed for peptic ulcer in combination with other medicines and also used in anesthesia as preoperative medication. It reduces acid and saliva secretions.  

When should Glycopyrrolate not to be taken? (Contraindications)

Contraindicated in patients with glaucoma, trouble urinating (eg, bladder neck obstruction), certain stomach or bowel problems (eg, stomach or bowel blockage, bowel muscle problems, severe ulcerative colitis, toxic megacolon), certain esophagus problems (eg, achalasia, reflux), or myasthenia gravis, and hypersensitivity.

What is the dosage of Glycopyrrolate?

IV/IM: Peptic Ulcer: 100mcg/kg, 3 to 4 times/day. In anesthetic: 4mcg/kg over 1hr.

How should Glycopyrrolate be taken?

It comes as a solution for injection, administered by a healthcare provider.

What are the warnings and precautions for Glycopyrrolate?

• Caution should be exercised in patients with history of pregnancy, breastfeeding, heart disease, increased level of thyroid hormone, liver or kidney impairment, enlarged prostate, diarrhea, fever, children and elderly people.

• It may cause ileus (abruption of gastrointestinal motor activity) or megacolon in patients with ulcerative colitis.

• Patient may develop dizziness or drowsiness; avoid driving a car or operating machinery while taking this medication.

• Avoid alcoholic beverages.

• Use appropriate solution if you are wearing contact lenses while taking this medication.

What are the side effects of Glycopyrrolate?

•  Most common: Dry mouth, difficulty in urinating, headaches, diarrhea and constipation.
•  Central Nervous System: Drowsiness, dizziness, problem in sleeping, headache, confusion and nervousness.
•  Heart: Irregular heart beat, cardiac arrest, high/low blood pressure and prolonged QT interval.
•  Skin: Itching, rash, redness and dry skin.
•  Respiratory: Respiratory arrest.
•  Gastrointestinal: Nausea; vomiting and loss of taste.
•  Hypersensitivity: Severe allergic reactions including anaphylactic/anaphylactoid reactions and hives.
•  Genitourinary: Impotence.
•  Miscellaneous: Fever and decreased sweating.
•  Potentially Fatal : Severe anaphylaxis.

What are the other precautions for Glycopyrrolate?

Avoid hot environments.

What are the storage conditions for Glycopyrrolate?

Injection: Store at 20-25°C. Store it at room temperature and in airtight container.


Schedule : H

Prescription drugs - Drugs to be sold only under the prescription of a Registered Medical Practitioner.
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