Glomerulonephritis Types

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About Minimal Change Disease

Minimal Change Disease

Minimal change disease is the most common cause of the nephrotic syndrome in childhood. In a prospective study of untreated children with the nephrotic syndrome, minimal change disease was found in 76.6%. 

In contrast, minimal change disease accounts for only 10% to 30% of adult cases of nephrotic syndrome. In both children and adults these percentages vary in different parts of the world. The clinical onset of nephrotic syndrome may be associated with an upper respiratory infection or with routine prophylactic immunizations. Other genetic and environmental factors may also be important. 

Clinical Course

Most patients with minimal change disease develop mild periorbital edema as the initial complaint. 
The proteinuria in minimal change disease is said to be "selective", that is composed primarily of albumin. Microscopic hematuria is rare with reported frequencies of 13 to 36%, and hypertension is also unusual in minimal change disease. 

Most patients (90%) respond to an 8 week course of steroids. Cytotoxic agents may be used in steroid resistant cases (~10%). Renal failure from minimal change disease is rare, but relapses are common.

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i was diagnosed with mpgn type 2 at 4 yrs old... it all started with a persistant cold. My mom always thought i was pale but, she had no idea until she found me lethargic on the floor.. my blood pressure was sky high. my urine was black. my 14 yr treatment consisted of aggressive doses of prednisone and blood pressure medication. i also give all the credit in the world to the doctors and staff at the Motts childrens hospital in ann arbor michigan.
breanna Thursday, February 04, 2010
my stepmom has minimal change disease- she also has rhem.arthritis- last week relapsed into MCD- her ankles are swolen to painful- Is there anybody who knows what foods are for her to eat???? She also suffers from celiac and is under 100 lbs- Please help!!
Tamara Harchanko Thursday, November 13, 2008
to whom it may concern... I am a 20 year old servivor of MPGN. i was diagnosed at 4 and have now been in remission for 4 years. ive never had a transplant, and although i was very close to it ive never been on dialysis.
breanna Monday, July 07, 2008
Hi bree. Glad to hear you are a survivor of MPGN. I am from ireland and my brothers little girl took this disease 9 weeks ago. She is on dialayis ever day and we are very concerned for her. I would be greatly obliged and grateful to hear the full story of your experiences and any advice you could offer me. Thankyou for you time and take care, colin
no1keene Thursday, August 21, 2008
it all started with a persistant cold.. after about two months of an upper respertory infection my mom found me lethargic on the floor.. my urine was black it was mpgn type 2.
breanna Thursday, February 04, 2010
Hi Bree! My daughter was diagnosed with MPGN type 1 in 2004, she continues to have problems with anemia, seems to be getting worse. Just wondering if you had the same problem?
guest Monday, April 06, 2009

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