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Over-The-Counter Drugs May Prevent Alzheimer's

by Medindia Content Team on  November 9, 2001 at 12:11 PM General Health News   - G J E 4
Over-The-Counter Drugs May Prevent Alzheimer's
Certain over-the-counter pain relievers commonly used to counter the pain and inflammation of rheumatoid arthritis also may cut the risk of getting Alzheimer's disease. In addition to their anti-inflammatory properties, the drugs seem to selectively reduce levels of a harmful protein linked to the neurodegenerative disease. The study developed from research suggesting that people taking certain NSAIDs regularly were less likely to develop Alzheimer's disease.
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The study suggests that three types of non-steroidal anti-inflammatory drugs (NSAIDs) markedly reduce production of a protein linked to the amyloid-beta plaque characteristic of Alzheimer's disease. The plaque collects in the brain and interferes with the ability of nerves to communicate with each other.

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The study showed that ibuprofen, indomethacin and sulindac sulphide lowered the production of the amyloid-beta 42 (AB42) protein, which helps to form the plaque believed to cause Alzheimer's. The three drugs reduced AB42 levels nearly 80 percent in cultured cells. However, the better-known NSAIDs, such as aspirin, Celebrex and Vioxx, had no such effect.

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