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Mannotriose Improves Learning and Memory

by Bidita Debnath on  January 7, 2014 at 10:55 PM Research News   - G J E 4
Mannotriose, the main component of the Chinese herb Rehmannia, can improve learning and memory.
 Mannotriose Improves Learning and Memory
Mannotriose Improves Learning and Memory
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Dr. Lina Zhang and colleagues from Shanghai University of Traditional Chinese Medicine in China used 1 × 10 mol/L mannotriose to treat primary hippocampal neurons insulted with 1 × 10 mol/L corticosterone.

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They found that hippocampal neuron survival rates and protein levels of glucocorticoid receptor, serum and glucocorticoid-regulated protein kinase, and brain-derived neurotrophic factor were all dramatically decreased after high-concentration corticosterone-induced injury. This effect was reversed by mannotriose, to a similar level as RU38486 and donepezil.

These findings, published in the Neural Regeneration Research (Vol. 8, No. 32, 2013), indicate that mannotriose could protect hippocampal neurons from high-concentration corticosterone-induced injury.

The mechanism by which this occurred was associated with levels of glucocorticoid receptor protein, serum and glucocorticoid-regulated protein kinase, and brain-derived neurotrophic factor.

Source: Eurekalert
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