Medindia

X

Activation of Estrogen Receptor-Beta can Help Reduce Obesity, Metabolic Diseases

by Dr. Trupti Shirole on  October 17, 2016 at 4:08 PM Obesity News   - G J E 4
Safe and effective treatment for obesity is highly needed. Activating the estrogen - the primary female sex hormone - receptor-beta protein with a chemical has the potential to increase metabolism as well as help reduce obesity, suggested researchers including one of Indian-origin.
 Activation of Estrogen Receptor-Beta can Help Reduce Obesity, Metabolic Diseases
Activation of Estrogen Receptor-Beta can Help Reduce Obesity, Metabolic Diseases
Advertisement

The findings showed that the activation of a chemical called beta-LGND2 by the estrogen receptor-beta can help reduce obesity and metabolic diseases in mice by converting bad fat (white fat) into good fat (brown fat).

‘Activating the estrogen receptor-beta protein with a chemical has the potential to increase metabolism as well as help reduce obesity.’
Advertisement
This is significant as brown fat increases metabolism and may facilitate weight loss, the researchers said.

"Although there is a general misperception that obesity is not a life-threatening condition, obesity is the underlying cause for several diseases that could result in mortality," said Ramesh Narayanan, a researcher at the University of Tennessee in the US.

"Safe and effective treatment for obesity is highly needed, and targeting estrogen receptor-beta might be one of the strategies to safely combat obesity," Narayanan added.

To make their discovery, Narayanan and colleagues used three groups of mice.

One group was fed with normal rodent diet, while two groups were fed with high-fat diet to make them obese. One of the two high-fat diet-fed groups was treated with beta-LGND2.

The beta-LGND2-treated mice were significantly leaner than the other mice fed on high-fat diet and they also had higher body temperature and oxygen consumption, indicating higher metabolism rate.

The research was published online in The FASEB Journal.

Source: IANS
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All