Medindia

X

Western Diets Trigger Obesity Genes

by Rajshri on  December 1, 2009 at 9:28 PM Genetics & Stem Cells News   - G J E 4
 Western Diets Trigger Obesity Genes
New research has shown that Western diets trigger genes that ultimately make us obese.
Advertisement

This means that these foods hit us with a double-whammy as the already difficult task of converting high-fat and high-sugar foods to energy is made even harder because these foods also turn our bodies into "supersized fat-storing" machines.

Advertisement
In the new study, scientists showed that foods high in fat and sugar stimulate a known opioid receptor, called the kappa opioid receptor, which plays a role in fat metabolism.

When this receptor is stimulated, it causes our bodies to hold on to far more fat than our bodies would do otherwise.

Study author Traci Ann Czyzyk-Morgan said that "the data presented here support the hypothesis that overactivation of kappa opioid receptors contribute to the development of obesity specifically during prolonged consumption of high-fat, calorically dense diets."

To make this discovery, Czyzyk-Morgan and her colleagues conducted tests in two groups of mice.

One group had the kappa opioid receptor genetically deactivated ("knocked out") and the other group was normal. Both groups were given a high fat, high sucrose, and energy dense diet for 16 weeks.

While the control group of mice gained significant weight and fat mass on this diet, the mice with the deactivated receptor remained lean.

In addition to having reduced fat stores, the mice with the deactivated receptor also showed a reduced ability to store incoming nutrients.

Although more work is necessary to examine what the exact effects would be in humans, this study may help address the growing obesity problem worldwide in both the short-term and long-term.

The study appears online in The FASEB Journal.

Source: ANI
RAS
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All