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Scientists Identify Genes That Help Predict Response to Treatment in Melanoma

by Rajashri on  June 1, 2009 at 7:31 PM Genetics & Stem Cells News   - G J E 4
 Scientists Identify Genes  That  Help  Predict Response  to Treatment in Melanoma
Researchers from the University of Pittsburgh Cancer Institute have identified eight genes that help predict a melanoma patient's response to treatment.

The findings have been presented at the 45th annual meeting of the American Society of Clinical Oncology (ASCO).
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"Approximately 70,000 people will be diagnosed with metastatic melanoma this year," said principal investigator Hussein Tawbi, M.D., M.Sc., assistant professor of medicine, University of Pittsburgh School of Medicine, and with UPCI's Melanoma Program.

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"This form of cancer is aggressive and often resistant to chemotherapy. In fact, only 7 to 10 percent of patients are likely to respond to the current standard of care. We wanted to see if there was a way to predict which patients would respond to treatment and which ones would not," the expert added.

To reach the conclusion, Tawbi and his colleagues examined the tumor tissues of 21 patients with metastatic melanoma, some of whom responded to chemotherapy and some who did not. Once the cases were divided, the researchers used a mathematical tool called Neural Network Analysis to survey over 25,000 genes and the regulators that turn the genes on and off to see if they could identify ones that could distinguish responders from nonresponders.

"Cancer cells contain massive amounts of information that, if analyzed appropriately, may inform us how to kill them," said Tawbi.

"They contain thousands of genes, and every gene has a switch that turns it on or off. Neural Network Analysis, which utilizes pattern recognition algorithms, helped us identify a signature of eight genes and their switches that predict a patient's likelihood of responding to treatment for metastatic melanoma," the expert added.

"The genes that we isolated in this study could be potential targets for new therapies down the road," explained Tawbi.

Source: ANI
RAS
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