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Pediatric OSA may Have New Drugs Soon
"We found that in the tonsil tissues of children with OSA, certain genes and gene networks were over expressed," said David Gozal, M.D., professor and chair of the Department of Pediatrics, who led the study. "We believe that the results of this gene overexpression is increased proliferation of the adenotonsillar tissues, which in turn can cause partial or complete obstruction of the upper airways during sleep."
The findings have been published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.
In the United States, two to three percent of children have OSA. The current standard of treatment is surgical removal on the tonsils, but surgery is not without risks and potential complications. Currently, about 600,000 tonsillectomies are performed each year in children, primarily to treat OSA.
Dr. Gozal and colleagues have been studying potential non-surgical alternatives to treat OSA in children. To identify potential pharmacological targets, they recruited 18 children with OSA and 18 age-, gender-, and ethnicity-matched children with recurrent tonsillar infections (RI), all of who underwent surgery to have their tonsils removed.
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