Waves of electrical discharge that start up in the human brain after a stroke are known as depolarisation waves. German experts now say these waves pose a risk even to the unaffected areas of the organ.
Researchers from the university hospitals of Heidelberg and Cologne, who joined hands with collaborators from the Max Planck Institute of Neurological Research in Cologne for this study, say that depolarisation waves arise at the edges of the dead tissue and spread through the adjacent areas of the brain.
The researchers say that a repetition of such waves may cause more cells to die.
Although the same discovery has previously been observed in animal studies, the researchers claim to be the first to show that this phenomenon occurs after a stroke in humans, and is a warning sign that more nerve cells will die.
A research article in the journal 'Annals of Neurology' says that this study may help translate more than 60 years of experimental research for the diagnosis and therapy of stroke patients.
"After the stroke, circulation in the tissue surrounding the affected area of the brain is initially poor, but it can still be saved," said Dr. Christian Dohmen of the Neurology Department at Cologne University Hospital.
The researcher, who also happens to be the main author of the study, says that the spreading depolarisations additionally impair the metabolism of the weakened nerve cells.