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Breakthrough Procedure To Help Prevent Organ Rejection
The transplanted bone marrow produces immune cells which are tolerant of the donated organ even when it is a genetic mismatch, according to the study published in the New England Journal of Medicine.
"We are very encouraged by our initial success in inducing tolerance across the HLA (mismatched human leukocyte antigen protein) barrier, something that has been a major goal of transplant immunology for years," said senior author David Sachs, director of the Massachusetts General Hospital Transplantation Biology Research Center.
"While we need to study this approach in a larger group of patients before it is ready for broad clinical use, this is the first time that tolerance to a series of mismatched transplants has been intentionally and successfully induced."
Sachs and his team have been working on a means to trick the immune system into regarding a donor organ as "self" for more than three decades.
They discovered that transplanted bone marrow creates a state called mixed chimerism where the immune system blends elements of both the donor and recipient.
They first used this approach in 1998 with a woman whose kidney failure had been caused by bone marrow cancer.
She was able to stop using immunosuppressant drugs about two months after her sister, who was a genetic match, donated bone marrow and a kidney and she remains healthy nine years later.
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mark12707@gmail.com(Guest)
03/19/2009
I am a liver recipient any hope I can get off meds?
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