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Biologic Therapies Valuable Option for Inflammatory Bowel Disease
However, researchers warn that doctors need to consider the potential associated side effects in determining treatment course.
IBD includes Crohn's disease and ulcerative colitis, both frequently disabling diseases.
The study was conducted by a team of researchers led by Stephen B. Hanauer, at the University of Chicago, and Paul Rutgeerts at University Hospital Gasthuisberg, Belgium.
As part of the study, researchers examined the literature on monoclonal antibodies or antibody fragments currently approved by the FDA or likely to be approved in the near future to study the side effects of biologic agents.
Researchers found that that for patients in whom traditional therapies do not work, through traditional 'step up' or sequential treatment approach biologics might be appropriate as a first line treatment. However, IBD is a heterogeneous disease and some patients may not respond to biologics, so the appropriate role of these agents in the treatment paradigm is the subject of much discussion.
The study noted that in determining the appropriate course of treatment, gastroenterologists needed to balance the potential complications of drug treatment (including increased risk for infections and cancer) against the consequences of potential under-treatment of their patients' disease (including poor quality-of-life, complications of disease, and the costs associated with active disease and the treatment of complications).
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More News on: Colo-rectal cancer - Management, Crohns Disease
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