How to Take Aliskiren and Amlodipine and Dose of Aliskiren and Amlodipine


Find out how to take Aliskiren and Amlodipine (drug) and its dose. Describes the best time to take the drug and precautions if any that should be followed.

How to take Aliskiren and Amlodipine


How it should be taken  

It comes as a tablet to take by mouth, with or without food.

Dosage & When it is to be taken

The recommended initial once-daily dose is 150mg/5 mg. Titrate as needed to a maximum of 300-mg/10 mg.

When it is not to be taken (Contraindications) 

Contraindicated in patients with diabetes, and hypersensitivity.
Do not use aliskiren with angiotensin receptor blockers (ARBs) and the angiotensin converting enzyme inhibitors (ACEIs)in patients with diabetes.

Why it is prescribed (Indications)  

This combination medication contains renin inhibitor and calcium channel blocker, prescribed for high blood pressure.  Amlodipine relaxes (widens) blood vessels where as Aliskiren inhibits renin and increase the blood flow.

Pregnancy Category

Category D : There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Warnings and Precautions  

Caution should be exercised in patients with history of angioedema, dehydration, low blood volume, high blood potassium, low-salt (sodium) diet, gout, heart, liver or kidney disease, low blood pressure, blood vessel problems, diabetes, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.
It may cause dizziness, lightheadedness, or fainting, do not drive a car or operate machinery and get up slowly from bed while taking this medication.
It may cause a serious side effect called angioedema, with the following symptoms: swelling of the hands, face, lips, eyes, throat, or tongue; difficulty in swallowing or breathing or hoarseness. If it is so consult with your healthcare provider.
Monitor blood pressure, kidney function, and blood electrolyte levels.

Storage Conditions  

Store at 25C. Protect from heat and moisture.
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