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General Information on Nilotinib

Generic Name : Nilotinib

Pronunciation : nye-LOE-ti-nib

Latest prescription information about Nilotinib. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.

Trade Names/Brand Names of Nilotinib

International- Tasigna.

Why is Nilotinib Prescribed? (Indications)

This medication is a tyrosine kinase inhibitor, prescribed for leukemia. It prevents the growth of cancer cells.

When should Nilotinib not to be taken? (Contraindications)

Contraindicated in patients with low blood potassium or magnesium levels, long QT syndrome (irregular heartbeat), and hypersensitivity.

What is the dosage of Nilotinib?

PO- The recommended dose is 300 mg orally twice daily.

How should Nilotinib be taken?

It comes as a capsule to take by mouth, without food.

What are the warnings and precautions for Nilotinib?

Caution should be exercised in patients with history of bone marrow depression, decrease in complete blood count, heart, kidney, or liver problem, abnormal blood electrolyte level, lactose intolerance, any allergy, who are taking other medications, during pregnancy and breastfeeding.
It may cause dizziness, do not drive a car or operate machinery while taking this medication.
It may reduce platelet counts; avoid injury or bruising.
Avoid contact with people who have infections.
Avoid live vaccination during the treatment period.
It may lead to dehydration; drink plenty of water or fluid to avoid this problem.
Monitor ECG, liver function, pancreas function, blood cholesterol, blood electrolyte levels, and complete blood cell counts regularly while taking this medication.

What are the side effects of Nilotinib?

   Most Common : Rash, itching, headache, nausea, fatigue, muscle pain, upper abdominal pain, hair loss, constipation, diarrhea, dry skin, muscle spasms, joint pain and abdominal pain.
   Central Nervous System : Dizziness, tingling and sensory loss.
   Eye and ENT : Eye bleeding, itching in the eye, eye inflammation, dry eyes and inner ear damage.
   Heart : Chest pain, abnormal heart rhythm, palpitations, high blood pressure and flushing.
   Respiratory : Difficulty in breathing, nosebleed, cough and voice impairment.
   Gastrointestinal : Inflammation of pancreas, abdominal discomfort, abdominal distension, indigestion, and flatulence.
   Skin : Night sweats, hives, redness, increased sweating, bruising, pimples, skin inflammation, dry skin.
   Musculoskeletal : Bone pain, muscle pain and flank pain.
   Genitourinary : Breast pain, breast enlargement in male and impotence.

What are the other precautions for Nilotinib?

Avoid excess dosage.

What are the storage conditions of Nilotinib?

Store it at room temperature (25C).

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