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Cytarabine

Latest prescription information about Cytarabine. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Cytarabine
Pronunciation : sye tare' a been
Therapeutic Classification : Chemotherapy
Trade Name(s): 
India- Arasid Vial, Biobin Inj, Cancyt Vial, Cybin-Pf Vial, Cytabin Vial, Cytalon Inj, Cytarabin Inj, Cytarabine Vial, Cytaraside Vial, Cytarine Vial, Cytrosar Vial, Oncotar Vial, Remcyta Vial, Zecyte Inj.
International- Cytosar-U, DepoCyt.
Why it is prescribed (Indications) : 
This medication is a chemotherapy agent, prescribed for acute myeloid leukemia (AML) and non-Hodgkin lymphoma. This medication slows the growth and spread of cancer cells in the body.  
When it is not to be taken (Contraindications): 
Hypersensitivity.

Pregnancy Category :

A B C D X
Category D : There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
IV/SC- The recommended dose is 100 mg/m2/day (days 1 to 7) or 100 mg/m2 IV every 12 hours (days 1 to 7).
How it should be taken : 
It comes as a solution for injection to be administered by a healthcare into the vein.
Warnings and Precautions : 
* Caution should be exercised in patients with history of liver and kidney dysfunction, severe infections, preexisting drug-induced bone marrow suppression, any allergy, who are taking other medications, children, during pregnancy and breast-feeding.
* It may cause drowsiness, do not drive a car or operate machinery while taking this medication.
* It may decrease platelet counts, which leads to severe bleeding; avoid injury or bruising.
* Monitor complete blood cell counts, liver and kidney functions regularly while taking this medication.
* Avoid drinking alcoholic beverages and citrus fruit juices.
Side Effects : 
Most Common - Bone marrow suppression, loss of appetite, nausea, vomiting, diarrhea, mouth ulcer, fever and rash.
Central Nervous System - Headache, dizziness, seizures, drowsiness, depression, anxiety, coma, incoordination, speech disorder and vision loss.
Respiratory - Lung swelling and cough.
Musculoskeletal - Muscle pain, neck pain and muscle stiffness.
Genitourinary - Increased urinary retention.
Eye - Blurred vision.
Skin - Increased sweating.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it at controlled room temperature (25°C).


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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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