One tends to associate low and deficient platelet counts or thrombocytopenia with viral infections like dengue, HIV, chickenpox. However, deficiencies of folate and vitamin B12, alcohol consumption, leukemia, chemotherapy, medication side-effects, autoimmune conditions, bypass surgery, idiopathic thrombocytopenic purpura (bleeding disorder) and host of other reasons can lead to breakdown of platelets in liver, spleen, and blood; insufficient platelet production in the bone marrow; or low platelet count in the blood owing to platelets sequestration in the spleen. Platelets are responsible for blood clotting. However, folic acid or vitamin B9; vitamin B12; vitamin C and omega-3 fatty acids provide support for the healthy functioning of platelets. Our general food habits can combat the fall or destruction of platelets. Severe cases, though, will need medical attention.