Creator: Dr. Reeja Tharu
Keywords: Y-Chromosome Microdeletions, azoospermia, oligospermia, male factor, spermatogenesis, tissue, AZFa, AZFb, AZFc, thymosin, RNA, testis, pseudogenes, metabolism, gene

Written by Dr. Reeja Tharu, M.Phil.,Ph.D
Medically Reviewed by The Medindia Medical Review Team on Nov 04, 2016

AZFa and candidate genes:

The size of the AZFa region is estimated to be 1Mb. The frequency of deletions in AZFa is lower than that of both AZFb and AZFc.

The important candidate genes include USP9Y (ubiquitin- specific protease 9, Y chromosome) and DBY (dead box on the Y).

USP9Y is a single copy gene that functions as a C-terminal ubiquitin hydrolase. It is ubiquitously expressed in a wide variety of tissues.

DBY is ubiquitously expressed in humans. In addition it exhibits transcripts unique to the testis. The protein it encodes is an RNA helicase. DBY is more frequently deleted than USP9Y.

The other candidate genes include UTY (ubiquitous TPR motif on the Y) and TB4Y (thymosin B4-isoform).

Published on Sep 06, 2014
Last Updated on Nov 04, 2016

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