Last Updated on Sep 23, 2020

Blood Donor Screening

Blood Screening Test

The primary tests recommended by the World Health Organization (WHO) are four in number. They are -

  • Surface Antigen (HbsAg) for Hepatitis B
  • Antibody to Hepatitis C
  • HIV antibodies (for subtypes 1 and 2)
HIV Antibodies
  • Serology test for Syphilis

In 2006, a WHO survey revealed that in 56 of 124 countries where the survey was carried out these basic tests were not done. Besides these core tests recommended by the WHO a variety of other tests are also carried out depending on the local need. Some of these include tests for variant Creutzfeldt-Jakob Disease (v CJD), West Nile Virus, cytomegalovirus and the HIV nucleic acid test (p24 antigen) that may help to detect a recently infected donor. The cytomegalovirus has negligible effect on a healthy recipient but may prove to be harmful on immuno-compromised patients, infants or pregnant women.

It is also mandatry that blood donors should be free of fever a fortnight prior to donating blood. They should also be free of diseases such as Malaria and Filaria.

Cross matching is also carried out before transfusions. Here the plasma of the recipient is tested for antibodies against the antigens on the red blood cells of the donor blood. If agglutination takes place, the blood is not compatible and transfusion cannot take place. If there is no agglutination the blood can be transfused.

In case of emergency, however, ABO and Rh compatible blood is used for transfusion, which may be non cross - matched.


  1. Donors who give blood voluntarily and for altruistic reasons have the lowest prevalence of HIV, hepatitis viruses and other blood-borne infections, as compared to people who donate for family members or in lieu of payment.
  2. WHO Fact sheet N279, June 2008, Blood safety and donation


Shazidamain Friday, June 14, 2013

According to a recent survey conducted by World Health Organisation, 52.42% of all blood donated in India is through voluntary blood donation camps. The figure was 45% in 2002. This shows that nearly 47.58% of all blood donated is either from paid donors or from family members.

sriharsha.d Wednesday, April 24, 2013

i have donated my blood on 22 feb 2013. can i donate it again on 24 april 2013? i'm of 19 years

purnima.rajput Monday, April 22, 2013

kya jb koi physical ho to last night kya woh blood de sakta hai.....

Michael48 Wednesday, January 23, 2013

Can I donate at a childrens' hospital if i am taking balsalazide disodium fo colitis?

Dominik Tuesday, December 11, 2012

Can I donate blood if a smoked weed ?

View More Comments

Most Popular on Medindia