Unique attributes of zebrafish make it useful as a model system for performing large-scale forward genetic screens.
Understanding Hematopoiesis may be Simplified by Systems Biology
It is a tenet of basic biology that our body reacts to blood loss by stimulating the production of red blood cells (erythrocytes).
It is a tenet of basic biology that our body reacts to blood loss by stimulating the production of red blood cells (erythrocytes).
‘Genetic regulation of the various types of blood cells in zebrafish and humans is highly similar, making it easier for understanding blood disorders using this organism.’
In the article “Fish to Learn: Insights into Blood Development and Blood Disorders from Zebrafish Hematopoiesis," the authors discuss the unique attributes of zebrafish that make it useful as a model system for performing large-scale forward genetic screens to silence or over-express target genes to determine their function, chemical screens, live imaging of blood system development at the single cell level, and modeling of hematopoietic disorders and malignancies by inserting human genes to create transgenic zebrafish. This article is part of a Festschrift in honor of George Stamatoyannopoulous, Professor of Medicine and Genome Sciences, and Director, Markey Molecular Medicine Center, University of Washington, Seattle.
"Zebrafish have proven to be an extremely powerful model for understanding developmental biology, including the developmental biology of blood-forming tissues," says Editor-in-Chief Terence R. Flotte, Celia and Isaac Haidak Professor of Medical Education and Dean, Provost, and Executive Deputy Chancellor, University of Massachusetts Medical School, Worcester, MA. "The review from the Zon laboratory beautifully illustrates how critical such studies have been to broader progress in biomedicine, as has long been envisioned by pioneers of molecular medicine like Dr. George Stamatoyannopoulous."
Zebrafish Can Help Provide Genetic Answers: Research
Scientists report that research in zebrafish has helped identify the cause of an unknown genetic disorder affecting a boy and two of his uncles.
Scientists report that research in zebrafish has helped identify the cause of an unknown genetic disorder affecting a boy and two of his uncles.
Zebrafish Model Sheds Light on Treatment Approaches Needed for Learning and Memory Disorder
The learning and memory components of neurofibromatosis are distinct features that will likely need different treatment approaches.
The learning and memory components of neurofibromatosis are distinct features that will likely need different treatment approaches.
Zebrafish Embryos Help to Unravel Alzheimer's Disease
Zebrafish embryos provide new insights into neurodegenerative disease processes in the human brain. Scientists at VIB and KU Leuven identify the molecules responsible for this process.
Zebrafish embryos provide new insights into neurodegenerative disease processes in the human brain. Scientists at VIB and KU Leuven identify the molecules responsible for this process.
