Medindia
Advertisement

World's First Blood Test for Celiac Disease Diagnosis

by Colleen Fleiss on August 10, 2019 at 5:50 PM
Font : A-A+

World's First Blood Test for Celiac Disease Diagnosis

Scientists have discovered distinct markers in the blood of people with celiac disease within a few hours of gluten.

The findings address a longstanding mystery about what drives the adverse reaction to gluten in coeliac disease and could lead to a world-first blood test for diagnosing the disease. A potential blood-based test would be a vast improvement on the current approach which requires people to consume gluten for a number of weeks, and even months, for the testing to be accurate. The research, published today in Science Advances, involved an international collaboration of the world's leading coeliac disease experts.

Advertisement


The peer-reviewed study included the Walter and Eliza Hall Institute of Medical Research in Australia, University of Oslo in Norway, and in the U.S., Massachusetts General Hospital and University of Chicago. The study was led by Boston-based biotechnology company ImmusanT Inc. Associate Professor Jason Tye-Din, head of coeliac research at the Institute and a gastroenterologist at The Royal Melbourne Hospital said work was now underway to explore the development of a simple blood test for coeliac disease.

"For the many people following a gluten-free diet without a formal diagnosis of coeliac disease, all that might be required is a blood test before, and four hours after, a small meal of gluten. "This would be a dramatic improvement on the current approach, which requires people to actively consume gluten for at least several weeks before undergoing an invasive procedure to sample the small intestine," Associate Professor Tye-Din said.
Advertisement

Coeliac disease affects approximately 1.4 per cent of people globally, many of whom remain undiagnosed. Symptoms of the disease are caused by a damaging immune response to gluten. After consuming gluten, patients can experience reactions such as nausea, vomiting, abdominal pain and diarrhoea.

Dr Bob Anderson, a joint senior author of the paper and the Chief Scientific Officer of ImmusanT Inc., said the new findings could address an important medical need.

"For the first time we have described the inflammatory reaction that patients with coeliac disease experience in the immediate hours after they are exposed to gluten.

"The unpleasant symptoms associated with the disease are linked to an increase in inflammatory molecules in the bloodstream, such as interleukin-2 (IL-2), produced by T cells of the immune system. This response is similar to what happens when an infection is present, however for people with coeliac disease, gluten is the trigger.

"This information underpins a potential new approach to diagnosis that addresses the emerging medical need to identify patients without coeliac disease who may be better served by other treatments for their chronic symptoms," Dr Anderson said.

Researchers at ImmusanT first discovered the immune markers while assessing blood samples during the Phase 1 trial of a potential coeliac therapy called Nexvax2. Gastrointestinal symptoms in patients injected with the gluten peptides, particularly nausea and vomiting, correlated with higher levels of IL-2 in their blood.

Subsequent testing showed the consumption of gluten produced the same IL-2 response in people with coeliac disease.

CEO of Coeliac Australia, Ms Michelle Laforest, said the finding would be welcome news for the coeliac community in Australia.

"The potential for a one-off gluten challenge and blood test could make a significant difference to many thousands of Australians who report sensitivity to gluten but have been unable to tolerate the current testing approach.

"It is clear this research has the potential to revolutionise the current testing regime for coeliac disease globally," Ms Laforest said.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Sedentary Behavior Precipitates Night-Time Hot Flashes
Gonorrhea
World Alzheimer's Day 2021 - 'Know Dementia, Know Alzheimer's
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Thalassemia Undescended Testicles Varicocele Celiac Disease Quiz on Depression Autoimmune Disorders Testicle Pain - Symptom Evaluation Blood in Stools - Symptom Evaluation Bombay Blood Group Torsion Testis 

Recommended Reading
Celiac Disease
Celiac disease is labeled as a digestive disorder associated with malabsorption as well as an ......
Gluten-Free Diet
Are you gluten intolerant? Stay away from gluten allergy and celiac disease by shifting to ......
Quiz on Celiac Disease
Reactions to specific types of food are quite common. Many children suffer from milk and egg ......
Celiac Disease
Celiac disease is an auto-immune digestive disorder which affects the small intestine...
Autoimmune Disorders
Autoimmune disorders occur when the immune system fails to recognize the body as ‘self’ and attacks ...
Blood in Stools - Symptom Evaluation
Blood in stools results from bleeding that arises from any part of the digestive tract. Causes of bl...
Bombay Blood Group
Bombay blood group is a rare blood type in which the people have an H antigen deficiency. They can r...
Testicle Pain - Symptom Evaluation
A sudden, severe pain in the testis may be due to testicular torsion. Testicles inside the scrotum a...
Thalassemia
Thalassemia is an inherited blood disorder passed on through parental genes causing the body to prod...
Torsion Testis
Torsion occurs when the testis spins, twisting the spermatic cord, causing reduced blood flow and te...
Undescended Testicles
An undescended testicle / testis is one that has not descended into the scrotal sac before birth. It...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use