Without Intervention, a 70% Reduction in Strokes or Death in Patients With Brain AVMs: Study

In people with a brain arteriovenous malformation, interventional treatment by neurosurgery, neuroradiology or radiation therapy could be more dangerous than the disease itself, said an international clinical trial, co-directed by researchers from the University of Montreal Hospital Research Centre (CRCHUM). The findings of the study are published in The Lancet Neurology. "In other words, the risk of patients having a stroke or dying is at least three times lower," stated Dr. Stapf, a researcher at the CRCHUM and professor at the Université de Montréal. "We wondered what was better for the patient: to remove the malformation to prevent a stroke or to live with the malformation for several years? The results of our study are clear: in the long term, standard medical care is more beneficial for the patient than any intervention. This certainly shakes up conventional thinking about how to prevent stroke in these patients."

Before joining the neurovascular program at CHUM in 2015, Dr. Stapf worked at Lariboisière Hospital (Paris, France). He was already the principal co-author of this study and in charge of the European component.

A second phase of the study sought to evaluate whether early surgical intervention might reduce the risk of neurological deficits. "After a five-year follow-up period, we showed that there were twice as many patients with a disabling deficit after the interventions than medical management alone," pointed out Dr. Stapf.

An Extraordinary Study

In this international clinical trial named ARUBA (acronym for A Randomized trial of Unruptured Brain AVMs), 226 adult participants with an average age of 44 were recruited between 2007 and 2013 in 39 hospital centres located in nine countries. Among the members of this collaborative network, the CHUM was the most active centre in terms of recruitment in Canada. There were two other centres in Ontario.

These volunteer patients, who had never had a stroke and whose malformation was sometimes discovered by chance, were divided into two groups: the first would get standard medical care, while the second would receive standard care combined with invasive therapies (by neurosurgery, interventional neuroradiology or radiation therapy). They were followed for average periods of between 33 and 50 months.

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In 2014, under the supervision of Dr. Jean Raymond (interventional neuroradiologist), the CHUM launched TOBAS, an international study whose aim was to see whether the conclusive findings of the clinical trial ARUBA might also be valid for all patients with a neurovascular malformation, including those who had had a stroke in the past.

To date, the CHUM's neurovascular health program is the largest in Quebec and among the biggest in Canada: more than 800 stroke patients are admitted to the program every year. With its Centre de Référence des Anomalies Neurovasculaires Rares (referral centre for rare neurovascular abnormalities or iCRANIUM), the CHUM also offers a specialized multidisciplinary clinic dedicated to patients with several types of vascular malformations of the brain.

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Source-Eurekalert