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Using Amino Acid Transporters as Drug Targets

by Anjali Aryamvally on March 22, 2018 at 12:08 PM
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Using Amino Acid Transporters as Drug Targets

Study highlights the opportunities and challenges in using amino acid transporters as drug targets. The study published in SLAS Discovery, is authored by Prof. Stefan Broer, Ph.D. of the Australian National University.

Amino Acid Transporters as Disease Modifiers and Drug Targets provides an overview of methods used to identify new inhibitors for amino acid transporters and outlines cell and organ function where these can be used to modulate, prevent or to treat diseases.

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The review highlights the demand for better inhibitors of amino acid transport processes and outlines promising new strategies and targets to develop amino acid transporters as drug targets. Cancer cells, for instance, need essential amino acids to proliferate and metastasize. Amino acid transporters are essential for capturing of nutrients from blood vessels, which can be blocked by specific inhibitors.

This is an area of active research and a promising strategy to treat cancer. In the brain, amino acids serve as excitatory and inhibitory neurotransmitters, which are quickly removed to terminate nerve impulses. Amino acid transporters can be targeted to enhance inhibition or excitation, a strategy used to treat chronic pain and possibly schizophrenia and general brain damage.
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Amino acids are generated from the breakdown of protein nutrition and are required as nutrients for cell growth, neurotransmission in the brain and cellular metabolism. Blocking some of these functions can treat diseases such as cancer, diabetes and chronic pain.



Source: Eurekalert
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