Medindia LOGIN REGISTER
Medindia
Advertisement

Therapeutic Potential of SiRNA Drugs Boosted By Nanoparticles

by Rukmani Krishna on April 11, 2013 at 9:33 PM
 Therapeutic Potential of SiRNA Drugs Boosted By Nanoparticles

Great therapeutic potential is offered by new classes of drugs that can silence specific genes, such as small interfering RNAs (siRNAs). But the specific delivery of siRNAs to target cells to exert their effects remains a significant challenge.

A novel nanoparticle-based approach that enables more efficient delivery of siRNA drugs is presented in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc. publishers. The article is available on the Nucleic Acid Therapeutics http://www.liebertpub.com/nat).

Advertisement

Compared to a commonly used lipid-based transport agent, the cSCK nanoparticles described in this article better protected siRNAs from being degraded in the bloodstream and were associated with greater gene silencing efficiency of siRNA drugs.

The study authors, Yuefei Shen, Huafeng Fang, Ke Zhang, and John-Stephen Taylor, Washington University, St. Louis, MO, and Ritu Shrestha and Karen Wooley, Texas A&M University, College Station, TX, attribute the better gene silencing efficiency achieved with cSCKs with improved cell uptake of the siRNAs. They present their findings in the article "Effective Protection and Transfection of siRNA by Cationic Shell-Crosslinked Knedel-Like Nanoparticles (cSCKs)."
Advertisement

"The potential of siRNAs as therapeutic agents is immense, but we still have to develop better and more targeted delivery methods for many diseases," says Executive Editor Fintan Steele, PhD, SomaLogic, Inc., Boulder, CO. "The work of Shen and colleagues demonstrates that nanotechnology approaches are rapidly progressing towards the goal of meeting the challenge of delivery."

Source: Eurekalert
Font : A-A+

Advertisement

Advertisement
Advertisement

Recommended Readings

Latest Genetics & Stem Cells News

Early-Stage Stem Cell Trial for Progressive Multiple Sclerosis
Among MS patients, the stem cells showed a neuroprotective role, guarding nerve cells from further decline.
Human Genetics Unravels Mysteries of Digestive Disorders
New possibilities for research on digestive diseases have been set by complete decoding of the Y chromosome.
World's First CRISPR-Based Gene Therapy for Blood Disorders
UK has given the green light to the world's inaugural gene therapy for sickle-cell disease and thalassemia.
Genotype Linked to Short-Lifespan Affects 1 in 25 People
1 in 25 people had a genotype linked to short lifetime, which includes BRCA2 and LDLR genes, that reduced lifespan by seven years, and six years respectively.
Is Stem Cell Therapy a Breakthrough for Reversing Osteoarthritis?
The study findings help redefine osteoarthritis as a reversible loss of key cartilage stem cells, not just 'wear and tear'."
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Therapeutic Potential of SiRNA Drugs Boosted By Nanoparticles Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests