Have you ever wondered why you love chomping on raw broccoli while your best friend can't stand the healthy veggie in any form or guise?
Have you ever wondered why you love chomping on raw broccoli while your best friend can't stand the healthy veggie in any form or guise? Your genes may be a part of the reason, particularly your bitter taste genes. Over the past decade, scientists at the Monell Center and elsewhere have made headway in understanding how variants of bitter taste receptor genes can help account for how people differ with regard to taste perception and food choice.
However, some perplexing pieces of the puzzle remained, as two people with exactly the same genetic makeup can still differ markedly regarding how bitter certain foods and liquids taste to them.
Now, findings from Monell reveal that a person's sensitivity to bitter taste is shaped not only by which taste genes that person has, but also by how much messenger RNA – the gene's instruction guide that tells a taste cell to build a specific receptor – their cells make.
Under normal circumstances, people whose taste receptor cells make more messenger RNA (mRNA) for a given gene make more of the encoded receptor.
The findings add a new level of complexity to our understanding of the cellular mechanisms of taste perception, which may ultimately lend insight into individual differences in food preferences and dietary choices.
"The amount of messenger RNA that taste cells choose to make may be the missing link in explaining why some people with 'moderate-taster' genes still are extremely sensitive to bitterness in foods and drinks," said Monell taste geneticist Danielle Reed, PhD, who is an author on the study.
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Before the biopsy, people rated the intensity of various bitter and non-bitter solutions, including broccoli juice. Even though the subjects had the same 'middle-of-the road' genotype, their responses to some of the bitter substances varied over four orders of magnitude. Analyses revealed a direct relationship between mRNA expression and bitterness ratings of broccoli juice, with subjects having the most mRNA rating the juice as most bitter.
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Source-Eurekalert