Study finds a novel gene involved in maintaining body weight. The interaction between the "body weight" gene, GTRAP3-18 and pro-opiomelanocortin (POMC) in the hypothalamus regulate food intake and blood glucose levels. Inhibiting this interaction may one day prove to be a strategy for treating leptin/insulin resistant patients with obesity or type 2 diabetes. The study was published online in The FASEB Journal.
"Eating too much or too little could actually be a genetic problem, rather than an insulin issue," said Toshio Nakaki, M.D., Ph.D., a researcher in the Department of Pharmacology, Teikyo University School of Medicine, in Tokyo, Japan. "Drugs targeting the GTRAP3-18 gene could be therapeutic for obesity or appetite-related disorders."
"This revealing investigation opens a new window on what is likely to be a key regulatory loop in the food intake-weight control axis, with considerable therapeutic potential," said Thoru Pederson, Ph.D., Editor-in-Chief of The FASEB Journal.