About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Switching Off ANGPTL4 Gene Reduces Risk of Heart Attack

by Julia Samuel on March 9, 2016 at 12:19 PM
Font : A-A+

Switching Off ANGPTL4 Gene Reduces Risk of Heart Attack

ANGPTL4 (angiopoietin-like 4) gene, a mutant with the help of medication can significantly reduce the probability of heart attack by 50 percent.

"This discovery makes it considerably easier to develop new medications that simulate the effect of this mutation," said lead researcher Heribert Schunkert from Technical University of Munich in Germany.

Advertisement


"This gives follow-on research aiming at reducing heart attacks in the future a concrete goal," Schunkert added.

The team was on the lookout for correlations between gene mutations and coronary artery disease. They analysed 13,000 different genes from a pool of 200,000 participants - both heart attack patients and healthy people.
Advertisement

For a number of genes, the researchers registered a correlation, including the ANGPTL4 (angiopoietin-like 4) gene. Subjects with the mutated ANGPTL4 gene had significantly lower triglyceride values in their blood.

"The blood fat triglyceride serves as an energy store for the body. However, as with LDL (bad) cholesterol, elevated values lead to an increased risk of cardiovascular disease. Low values, by contrast, lower the risk," said Jeanette Erdmann from University of Lübeck in Germany.

"The triglycerides, on the other hand, are the second important blood fat, alongside the harmful LDL cholesterol," Schunkert stated.

The findings showed that the concentration of triglycerides in the blood are influenced not only by nutrition and predisposition, but also by the ANGPTL4 gene.

The mutations identified by the researchers disable the function of this gene and thereby ensure that the triglyceride value drops significantly.

"At the same time, we discovered that the body does not even need the ANGPTL4 gene and manages wonderfully without it. It seems to be superfluous," Erdmann stated.

Shutting down the gene or inhibiting the LPL enzyme in another manner may ultimately protect against coronary disease.

"Based on our results, medications now need to be developed that neutralize the effect of the ANGPTL4 gene, thereby, reducing the risk of a heart attack," Schuinkert explained.

Source: IANS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
World Heart Day in 2022- Use Heart for Every Heart
Anemia among Indian Women and Children Remains a Cause of Concern- National Family Health Survey-5
H1N1 Influenza Prevention in Children: What Parents Need to Know
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Chest Pain DNA Finger Printing Cardiac Catheterization Heart Attack Diet Lifestyle and Heart Disease Coronary Artery Bypass Grafting Stress and the Gender Divide Heart Attack Facts Heart Heart Attack- Lifestyle Risks 

Most Popular on Medindia

Daily Calorie Requirements Drug - Food Interactions Drug Side Effects Calculator The Essence of Yoga Blood Pressure Calculator Hearing Loss Calculator Accident and Trauma Care A-Z Drug Brands in India Nutam (400mg) (Piracetam) How to Reduce School Bag Weight - Simple Tips
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Switching Off ANGPTL4 Gene Reduces Risk of Heart Attack Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests