About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Study Shows How Our Immune System may Help Prevent Miscarriage

by Colleen Fleiss on July 18, 2021 at 5:10 PM
Font : A-A+

Study Shows How Our Immune System may Help Prevent Miscarriage

A class of immune cells that plays a key role in miscarriage has been discovered by researchers. Miscarriage affects about a quarter of pregnancies.

Researchers at University of California-San Francisco found that the recently discovered subset of cells known as extrathymic Aire-expressing cells in the immune system may prevent the mother's immune system from attacking the placenta and foetus.

Advertisement

The researchers showed that pregnant mice who did not have this subset of cells were twice as likely to miscarry, and in many of these pregnancies foetal growth was severely restricted.

"When you're pregnant, the immune system is seeing the placenta for the first time in decades -- not since the mother made a placenta when she herself was a foetus," said Eva Gillis-Buck, from UCSF.
Advertisement

"Our research suggests that this subset of immune cells is carrying out a sort of 'secondary education' -- sometimes many years after the better-known population of the educator cells have carried out the primary education in the thymus -- teaching T cells not to attack the foetus, the placenta and other tissues involved in pregnancy," she added. The findings are published in the journal Science Immunology.

"It was a conceptual leap to link Aire-expressing cells, which are critical for preventing autoimmune disease, to pregnancy," said Tippi Mackenzie, Professor of surgery at UCSF's Center for Maternal Foetal Precision Medicine.

In the thymus, Aire-expressing cells begin interacting with other immune cells very early in life to teach them what not to attack. The thymus begins to shrink and is nearly gone by adulthood, by which time most immune cells have been educated. But as the thymus shrinks, the population of eTACs in lymph nodes and the spleen expands, the researchers explained.

The study suggests a healthy pregnancy may depend on having these cells around, they added.

Source: IANS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test Your Knowledge on Kidney
World Disability Day 2022 - The Role of Innovative Transformation
Diet and Oral Health: The Sugary Connection May Become Sour
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Miscarriage Dilatation and Curettage Immunisation Myasthenia Gravis Abortion Stress and Miscarriage Methods of Abortion Incompetent Cervix Erythroblastosis Fetalis Maternal Death 

Most Popular on Medindia

Post-Nasal Drip A-Z Drug Brands in India How to Reduce School Bag Weight - Simple Tips Loram (2 mg) (Lorazepam) Pregnancy Confirmation Calculator Selfie Addiction Calculator Calculate Ideal Weight for Infants Find a Doctor Iron Intake Calculator Diaphragmatic Hernia
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Study Shows How Our Immune System may Help Prevent Miscarriage Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests