About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Study Sheds Metabolic Bone Disease in Cirrhosis Patients

by Rajashri on August 12, 2009 at 9:34 PM
Font : A-A+

 Study Sheds Metabolic Bone Disease in Cirrhosis Patients

Various studies have linked long-standing liver disease to an increased risk of fractures. The overall incidence in these studies has varied from 11% to 48%, with a fracture rate of 3%-44%.

However, the reason for this is poorly understood. With liver transplantation becoming a viable option in liver disease and offering complete cure and long-term survival, bone disease is becoming the major determinant of survival and quality of life in these patients.

Advertisement

A research article to be published on July 28, 2009 in the World Journal of Gastroenterology addresses this question. This research team was led by Tushar R Bandgar from KEM Hospital, India.

They found that low bone formation and increased resorption led to fragile bones in these patients. Contributing factors identified were inadequate sunlight exposure, reduced physical activity, low body weight, vitamin D deficiency and low level of testosterone. They also demonstrated that the severity of bone loss was accelerated in patients with low IGF-1 level. IGF-1 is normally synthesized in the liver and its synthesis is affected early in cirrhosis. The present study also found that the increased estrogen level seen in cirrhosis was protective against osteopenia.
Advertisement

These results shed new light on bone disorders seen in patients with cirrhosis. As most of the factors identified are correctable or treatable, it should provide additional help in treatment of these patients, such that they have better quality of life and survival.



Source: Eurekalert
RAS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Sensory Processing Disorder (SPD)
First Dose of COVID-19 Vaccines May Improve Mental Health
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Alcoholic Liver Disease Cleidocranial Dysplasia Infantile Cortical Hyperostosis Bubbles and Brews - Alcohol Facts Liver Syndrome X Renal Osteodystrophy / Mineral Bone Disorder Fatty Liver Disease: A Growing Health Problem in India Fibroscan for Fatty Liver Cirrhosis and Fibrosis Hepatorenal Syndrome 

Recommended Reading
Alcoholic Liver Disease
Encyclopedia section of medindia gives general information about Alcoholic Liver Disease....
Alcohol abuse
Alcohol abuse...
Alcohol and Driving
Alcohol and driving do not mix. Drunken driving is the cause of many deaths in the world....
Bubbles and Brews - Alcohol Facts
There is more to alcohol than mere intoxication. Infamous because of its social abuse but indispensa...
Cleidocranial Dysplasia
Cleidocranial dysplasia - Rubber man - Read about the condition where a person affected by this cond...
Fatty Liver Disease: A Growing Health Problem in India
Non alcoholic fatty liver disease (NAFLD) is the leading cause of liver dysfunction worldwide and is...
Fibroscan for Fatty Liver Cirrhosis and Fibrosis
Recently, Fibroscan has incorporated the noninvasive Controlled Attenuation Parameter technique to e...
Hepatorenal Syndrome
Hepatorenal syndrome (HRS) occurs in end stage cirrhosis and is marked by serious circulatory distur...
Infantile Cortical Hyperostosis
Infantile Cortical Hyperostosis is a disease of unknown cause, where bizarre thickening of the corti...
Renal Osteodystrophy / Mineral Bone Disorder
Renal Osteodystrophy which is referred to as Mineral Bone Disorder is a result of imbalance in calci...
Syndrome X
"Syndrome X" or "Metabolic syndrome" is a group of conditions that puts a person at risk for diabete...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use