About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Study Says Nanoparticles may Help Fight Disease

by Rajashri on July 31, 2008 at 3:32 PM
 Study Says Nanoparticles may Help Fight Disease

An ultra-miniature bialy-shaped particles called nanobialys that may soon be carrying medicinal compounds through patients' bloodstreams to tumours or atherosclerotic plaques have been developed by US scientists.

The particles dubbed nanobialys are being considered as a significant addition to the stock of diagnostic and disease-fighting nanoparticles developed by researchers in the Consortium for Translational Research in Advanced Imaging and Nanomedicine (C-TRAIN) at Washington University School of Medicine in St. Louis.

Advertisement

The scientists behind this work have revealed that the nanobialys resemble tiny versions of the flat, onion-topped rolls popular in New York City.

They say that the nanobialys' appealing shape was a natural result of the manufacturing process.

The researchers say that the nanobialys may provide an alternative to the gadolinium-containing nanoparticles, a common contrast agent for magnetic resonance imaging (MRI) scans that may be harmful to some patients with severe kidney disease.
Advertisement

"The nanobialys contain manganese instead of gadolinium. Manganese is an element found naturally in the body. In addition, the manganese in the nanobialys is tied up so it stays with the particles, making them very safe," says first author Dr. Dipanjan Pan, research instructor in medicine in the Cardiovascular Division.

The researchers say that the bulk of a nanobialy is a synthetic polymer that can accept a variety of medical, imaging or targeting components.

In the Journal of the American Chemical Society, the researchers report that targeted manganese-carrying nanobialys readily attached themselves to fibrin molecules, which are found in atherosclerotic plaques and blood clots.

Laboratory-made clots later glowed brightly in MRI scans, they say.

The researchers also say that the nanobialys can carry both water-soluble and insoluble drugs.

"When we looked at the particles with an electron microscope, we saw they are round and flat, with a dimple in the centre, like red blood cells, but also a little irregular, like bagels. I came across the word bialy, which is a Polish roll like a bagel without a hole that can be made with different toppings. So I called the particles nanobialys," said Pan, who is a research instructor in medicine, played a leading role in the creation of nanobialys and chose the particles' name.

The researchers have plans to continue adapting the nanobialys for a variety of medicinal applications, and work to develop other types of nanoparticles so that they can supply a wide range of medical needs.

Source: ANI
RAS/L
Font : A-A+

Advertisement

Advertisement
Advertisement

Latest Research News

Brain Circuits That Shape Bedtime Rituals in Mice
New study sheds light on the intrinsic, yet often overlooked, role of sleep preparation as a hardwired survival strategy.
NELL-1 Protein Aids to Reduce Bone Loss in Astronauts
Microgravity-induced bone loss in space, can be reduced by systemic delivery of NELL-1, a protein required for bone growth and its maintenance.
Connecting Genetic Variants to the Alzheimer's Puzzle
Researchers establish connections between Alzheimer's-linked genetic alterations and the functioning of brain cells.
Gene Therapy Sparks Spinal Cord Regeneration
Team at NeuroRestore introduces a groundbreaking gene therapy that has effectively promoted nerve regrowth and reconnection, post spinal cord injury.
Unlocking the Gut Microbiome's Influence on Bone Density
Scientists aim to pinpoint particular functional pathways affected by these bacteria that may have an impact on skeletal health.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
MediBotMediBot
Greetings! How can I assist you?MediBot
×

Study Says Nanoparticles may Help Fight Disease Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests