Eating disorders such as anorexia nervosa and bulimia nervosa are considered to be the result of genetic predisposition and environmental risk factors and a new research further explores the association. Despite eating disorders being common to families, no definitive genetic basis for disease predisposition has been identified. In this issue of the Journal of Clinical Investigation, Michael Lutter and colleagues at the University of Iowa identified genetic mutations in two separate families affected by eating disorders that were linked to the same transcriptional pathway. The researchers determined that a mutation in the gene encoding the transcription factor estrogen-related receptor α (ERRSA) correlated with eating disorder development in one family and a mutation in gene encoding the transcriptional repressor histone deacetylase 4 (HDAC4) associated with eating disorders in the second family. The mutant forms of both ERRSA and HDAC4 resulted in reduced expression of known ERRSA-dependent genes. These findings indicate that individuals with mutations that reduce ESRRA activity have an increased risk of developing eating disorders. Source: Eurekalert << Frequent Stroking Causes Stress to Cats Rushed Wedding After Groom Discovers He Has Few Months to L... >> Recommended Reading Bulimia Nervosa The term ''Bulimia'' refers to episodes of uncontrolled excessive eating, known as "binges," followed by self-induced vomiting or purgation. READ MORE Sleep Eating Disorders Sleep-related eating disorders are abnormal eating behaviors that occur during night. Sleep related eating disorder is a part of parasomnias. READ MORE Increased Appetite Symptom Evaluation An increase in appetite is seen in conditions like bulimia, diabetes, hyperthyroidism and worm infestation. READ MORE Anorexia Nervosa Anorexia nervosa is an eating disorder most commonly found among teenage girls. Anorexia nervosa is characterized by a very low body weight, generally defined as 15% below the Body Mass Index. READ MORE Binge Eating Disorder When a person overeats, he is unable to control his hunger pangs, while during an emotional/binge eating session, he is incapable of controlling his emotions. READ MORE Chronic Dieting - Is it an Eating Disorder? Chronic dieting is associated with eating disorders that mainly include unhealthy eating practices such as severe calorie restriction in diet of men or women who on a regular basis follow fad diets mainly to reduce weight. READ MORE Diabulimia Diabulimia is an eating disorder particularly in patients with type I diabetes caused by reducing and/or skipping insulin doses. READ MORE Loss of Taste Symptom of loss of taste usually occurs in combination with loss of smell and can be complete loss or partial loss of taste. It can also be temporary or permanent, though the latter is very rare. READ MORE Orthorexia Nervosa Are you a Health Food Junkie? Are you obsessed with what you eat all the time? You may be a victim of a condition called Orthorexia Nervosa. READ MORE Most Popular on Medindia A-Z Drug Brands in India Hearing Loss Calculator Drug - Food Interactions More News on: Binge Eating DisorderBulimia NervosaSleep Eating DisordersOrthorexia NervosaLoss of TasteDiabulimiaChronic Dieting - Is it an Eating Disorder?