Injection of heart stem/progenitor cells directly into the heart is one approach being developed as a way to improve heart function following heart attack. Now, a team of researchers, at Tokyo Women's Medical University, Japan, and Chiba University Graduate School of Medicine, Japan, has found that transplanting sheets of clonally expanded heart cells expressing the protein Sca-1 (cells that are heart stem/progenitor cells and that the authors term CPCs) improves heart function after a heart attack in mice. The team, led by Katsuhisa Matsuura and Issei Komuro, found that CPCs not only formed heart muscle cells but also secreted a soluble molecule (sVCAM-1) that induced the migration of endothelial cells (which help form new blood vessels) and CPCs and prevented heart muscle cells dying from oxidative stress. In the mouse model of heart attack, preventing sVCAM-1 from binding to the protein VLA-4 inhibited the formation of new blood vessels and blocked CPC migration and survival, leading to a decreased ability of the transplanted CPC sheets to improve heart function. The authors conclude that these data provide new insight into the mechanisms by which heart stem/progenitor cells improve heart function following heart attack. Source: EurekalertRAS << Study Sheds Light on How Noise and Nervous System Get in Wa... Changes in White Matter may be Able to Predict Dementia Ris... >> Recommended Reading Diet, Lifestyle and Heart Disease The correlation between diet, lifestyle and heart disease. The importance of balanced diet life style and exercise for controlling heart disease. READ MORE Congenital Heart Disease Heart diseases that are present at birth are called " Congenital heart diseases". READ MORE Heart Attack Heart attack is the death of the heart muscle due to loss of blood supply. Heart disease is the leading cause of death in the United States. Other names for heart attack include acute myocardial infarction, coronary thrombosis, and coronary ... READ MORE Heart Attack- Lifestyle risks Heart attack is the death of the heart muscle due to loss of blood supply. Simple guidelines to avoid heart attack are listed. READ MORE Cardiac Catheterization Cardiac catheterization is a radiological procedure for both diagnosis and treatment of heart conditions. It involves the insertion of a long thin flexible tube called catheter a vein or an artery to the heart. READ MORE Hyperventilation Hyperventilation occurs when a person breathes in excess to the body’s requirement. READ MORE Mitral Valve Prolapse Mitral Valve Prolapse is a relatively common condition and causes leakage of blood through the valve. MVP is not life-threatening in most instances. READ MORE Statins Statins are new wonder drugs that are proving to be efficacious, not merely in relieving symptoms but also offering several health benefits. READ MORE Stress and the Gender Divide Stress has become entwined in the current lifestyle of a young working couple and has resulted in the rise in incidence of hypertension, diabetes and psychosomatic illnesses. READ MORE Most Popular on Medindia Pregnancy Confirmation Calculator Nutam (400mg) (Piracetam) Sanatogen More News on: Cardiac CatheterizationHeart AttackDiet Lifestyle and Heart DiseaseStress and the Gender DivideHeartHeart Attack- Lifestyle RisksHealthy HeartHyperventilationStatinsMitral Valve Prolapse
Injection of heart stem/progenitor cells directly into the heart is one approach being developed as a way to improve heart function following heart attack. Now, a team of researchers, at Tokyo Women's Medical University, Japan, and Chiba University Graduate School of Medicine, Japan, has found that transplanting sheets of clonally expanded heart cells expressing the protein Sca-1 (cells that are heart stem/progenitor cells and that the authors term CPCs) improves heart function after a heart attack in mice. The team, led by Katsuhisa Matsuura and Issei Komuro, found that CPCs not only formed heart muscle cells but also secreted a soluble molecule (sVCAM-1) that induced the migration of endothelial cells (which help form new blood vessels) and CPCs and prevented heart muscle cells dying from oxidative stress. In the mouse model of heart attack, preventing sVCAM-1 from binding to the protein VLA-4 inhibited the formation of new blood vessels and blocked CPC migration and survival, leading to a decreased ability of the transplanted CPC sheets to improve heart function. The authors conclude that these data provide new insight into the mechanisms by which heart stem/progenitor cells improve heart function following heart attack. Source: EurekalertRAS << Study Sheds Light on How Noise and Nervous System Get in Wa... Changes in White Matter may be Able to Predict Dementia Ris... >> Recommended Reading Diet, Lifestyle and Heart Disease The correlation between diet, lifestyle and heart disease. The importance of balanced diet life style and exercise for controlling heart disease. READ MORE Congenital Heart Disease Heart diseases that are present at birth are called " Congenital heart diseases". READ MORE Heart Attack Heart attack is the death of the heart muscle due to loss of blood supply. Heart disease is the leading cause of death in the United States. Other names for heart attack include acute myocardial infarction, coronary thrombosis, and coronary ... READ MORE Heart Attack- Lifestyle risks Heart attack is the death of the heart muscle due to loss of blood supply. Simple guidelines to avoid heart attack are listed. READ MORE Cardiac Catheterization Cardiac catheterization is a radiological procedure for both diagnosis and treatment of heart conditions. It involves the insertion of a long thin flexible tube called catheter a vein or an artery to the heart. READ MORE Hyperventilation Hyperventilation occurs when a person breathes in excess to the body’s requirement. READ MORE Mitral Valve Prolapse Mitral Valve Prolapse is a relatively common condition and causes leakage of blood through the valve. MVP is not life-threatening in most instances. READ MORE Statins Statins are new wonder drugs that are proving to be efficacious, not merely in relieving symptoms but also offering several health benefits. READ MORE Stress and the Gender Divide Stress has become entwined in the current lifestyle of a young working couple and has resulted in the rise in incidence of hypertension, diabetes and psychosomatic illnesses. READ MORE Most Popular on Medindia Pregnancy Confirmation Calculator Nutam (400mg) (Piracetam) Sanatogen More News on: Cardiac CatheterizationHeart AttackDiet Lifestyle and Heart DiseaseStress and the Gender DivideHeartHeart Attack- Lifestyle RisksHealthy HeartHyperventilationStatinsMitral Valve Prolapse